DIGITAL HAND ATLAS IN ASSESSMENT OF SKELETAL DEVELOPMENT

描述：（摘自申请摘要）：骨龄评估是一项 经常在儿科患者中进行的程序，以评估 他们的成长。 一个人骨骼发育的放射学检查 左手手腕由于简单的优点而被普遍使用， 最小的辐射暴露和多骨化的可用性 成熟度评估中心。 这是一个重要的程序， 内分泌疾病的诊断和管理， 代谢和生长异常，成熟加速或减少 各种综合征、畸形和骨发育不良。 也是 在计划整形手术时咨询过 参考数据集，在20世纪30年代开发，并发表在 Greulich和Pyle地图集并不完全适用于当今的儿童。 的 一组X光片不能反映标准的发展，特别是 黑人女孩和白人男孩 基于匹配的诊断 诊断X线片与模式图像之一导致差异 从0.4年到0.9年不等。 本研究项目旨在开发一个数字地图集， 正常手部和腕部X光片标准集及相关 这些测量结果将成为计算机辅助骨龄的基础 考核 具体而言，本研究将探讨三个假设： (1)新的C@Cally正常图像参考集将用作数字手 阿特拉斯 (2)计算机辅助骨骼发育评估将 提取物 从患者图像中的放射学发现，并允许其 与从数字地图中提取的相应值的比较 用作更新的参考图像集。 (3)数据库系统 将存档图像数据和放射学发现， 允许他们从临床工作站访问。 为了测试这些 假设我们提出了以下六个具体目标：A.骨龄 评估方法和软件开发。 B。软件开发 对于用户界面和交互式 通信 C.参考图像集合的选择， 临床影像， 数据库系统 D.数字化手绘地图软件开发。 e.数据库的设计与实现。 F.的临床评价 计算机骨龄性能 考核 到本研究结束时，将有一个医学上可接受的标准集， 数字手图集可以作为参考。 它将删除 目前使用的一个缺点，不完整和过时。 一 计算机辅助图像分析将使诊断标准化 变得更加客观和可重复。所有发现（放射学和 临床）将存储在数据库中，以供将来参考， 提高计算机辅助骨龄评估的性能。

DESCRIPTION: (Taken from application abstract): Bone age assessment is a procedure frequently performed in pediatric patients in order to evaluate their growth. The radiological examination of skeletal development of a left hand wrist is universally used due to the advantage of simplicity, a minimum of radiation exposure, and the availability of multiple ossification centers for evaluation of maturity. It is an important procedure in the diagnosis and management of endocrine disorders, diagnostic evaluation of metabolic and growth abnormalities, acceleration or decrease of maturation in a variety of syndromes, malformations, and bone dysplasias. It is also consulted in planning an orthopedic procedure. The reference set of data, developed in the 1930's and published in the Greulich and Pyle atlas is not fully applicable for children of today. The set of radiographs does not reflect the standard development particularly of black girls and Caucasian boys. The diagnosis based on matching the diagnosed radiographs with one of the pattern image leads to a discrepancy ranging from 0.4 to 0.9 years. This research project intends to develop a digital atlas with a large standard set of normal hand and wrist radiographs and associated measurements which will form the basis for a computer-assisted bone age assessment. In particular, the research will investigate three hypotheses: (1) New reference set of c@cally normal images will serve as a digital hand atlas. (2) Computer-assisted assessment of skeletal development will extract radiological findings from a patient image and allow for their comparison with corresponding values extracted from the digital atlas serving as an updated set of reference images. (3) Database system will archive image data and radiological findings and allow their access from clinical workstations. In order to test these hypotheses we set forth the following six specific goals: A. Bone age assessment methodology and software development. B. Software development for the user interface and interactive communication. C. Selection of the set of reference images and clinical images for the database system. D. Software development for a digital hand atlas. E. Database design and implementation. F. Clinical evaluation of the performance of the computerized bone age assessment. By the end of this study there will be a medically accepted standard set of digital hand atlases able to be used as a reference. It will remove the disadvantages of the currently used one, incomplete and out-of-date. A computer-aided image analysis will permit the diagnosis to be standardized and become more objective and reproducible., All findings (radiological and clinical) will be stored in a database for future reference and for improvement of the performance of computer-assisted bone age assessment.