DIGITAL HAND ATLAS IN ASSESSMENT OF SKELETAL DEVELOPMENT

描述：(摘自申请摘要)：骨龄评估是一项 儿科患者经常进行的程序，以评估 他们的成长。骨质疏松症患者骨骼发育的X线检查 左手手腕由于简单的优点而被普遍使用， 最低限度的辐射暴露，以及多发性骨化的可用性 成熟度评估中心。这是一个重要的程序，在 内分泌疾病的诊断和治疗，诊断评估 代谢和生长异常，成熟度加速或降低 在各种综合征、畸形和骨发育不良中。它也是 在计划整形外科手术时进行咨询。 参考数据集，开发于1930年代的S，并在 格劳里奇和派尔地图集并不完全适用于今天的儿童。这个 一套射线照相并不反映标准的发展，特别是 黑人女孩和高加索男孩。基于匹配的诊断 诊断出的具有其中一个图案图像的X光片会导致不一致 从0.4到0.9年不等。 本研究项目旨在开发一种具有大型 正常手部和手腕X光片的标准集和相关 将构成计算机辅助骨龄的基础的测量 评估。特别是，这项研究将调查三个假设： (1)新的C@CALLY正常图像参考集将用作数码手 阿特拉斯。(2)骨骼发育的计算机辅助评估将 浸膏 患者影像的放射学发现，并允许他们的 与从数字地图集提取的对应值进行比较 作为一组更新的参考图像。(3)数据库系统 将图像数据和放射学发现存档，并 允许他们从临床工作站访问。为了测试这些 假设我们提出了以下六个具体目标：a.骨龄 评估方法和软件开发。B.软件开发 用于用户界面和交互 沟通。C.选择该组参考图像和 临床影像资料： 数据库系统。D.数字手绘图集的软件开发。 E.数据库的设计和实现。F.临床评价 计算机骨龄测定仪的使用性能 评估。 到这项研究结束时，将会有一套医学上可以接受的标准 可以作为参考的数字手绘图集。它将删除 目前使用的一种方法的缺点是不完整和过时。一个 计算机辅助图像分析将使诊断标准化 并变得更加客观和可重复性。所有的发现(放射学和 临床)将存储在数据库中，以供将来参考和 提高计算机辅助骨龄评估的性能。

DESCRIPTION: (Taken from application abstract): Bone age assessment is a procedure frequently performed in pediatric patients in order to evaluate their growth. The radiological examination of skeletal development of a left hand wrist is universally used due to the advantage of simplicity, a minimum of radiation exposure, and the availability of multiple ossification centers for evaluation of maturity. It is an important procedure in the diagnosis and management of endocrine disorders, diagnostic evaluation of metabolic and growth abnormalities, acceleration or decrease of maturation in a variety of syndromes, malformations, and bone dysplasias. It is also consulted in planning an orthopedic procedure. The reference set of data, developed in the 1930's and published in the Greulich and Pyle atlas is not fully applicable for children of today. The set of radiographs does not reflect the standard development particularly of black girls and Caucasian boys. The diagnosis based on matching the diagnosed radiographs with one of the pattern image leads to a discrepancy ranging from 0.4 to 0.9 years. This research project intends to develop a digital atlas with a large standard set of normal hand and wrist radiographs and associated measurements which will form the basis for a computer-assisted bone age assessment. In particular, the research will investigate three hypotheses: (1) New reference set of c@cally normal images will serve as a digital hand atlas. (2) Computer-assisted assessment of skeletal development will extract radiological findings from a patient image and allow for their comparison with corresponding values extracted from the digital atlas serving as an updated set of reference images. (3) Database system will archive image data and radiological findings and allow their access from clinical workstations. In order to test these hypotheses we set forth the following six specific goals: A. Bone age assessment methodology and software development. B. Software development for the user interface and interactive communication. C. Selection of the set of reference images and clinical images for the database system. D. Software development for a digital hand atlas. E. Database design and implementation. F. Clinical evaluation of the performance of the computerized bone age assessment. By the end of this study there will be a medically accepted standard set of digital hand atlases able to be used as a reference. It will remove the disadvantages of the currently used one, incomplete and out-of-date. A computer-aided image analysis will permit the diagnosis to be standardized and become more objective and reproducible., All findings (radiological and clinical) will be stored in a database for future reference and for improvement of the performance of computer-assisted bone age assessment.