CORE--OUTPATIENT FACILITY

门诊设施的目标是： 1.为项目1-5提供公共资源 门诊部(OPD)的设施对于 获取所需的临床数据以实现以下目标 各种各样的项目。正是在OPD中，对持续的 植入，肿瘤反应，急性和慢性移植物抗宿主病，表现 免疫缺陷、植入后感染和其他并发症 进行了骨髓移植。以及临床评估， 门诊部提供了一种获取血液和组织样本的方法 多名调查人员。 2.提供一种系统的方法来评价和管理 晚期并发症。多器官功能障碍的发生率和严重程度 骨髓移植后的毒性正在积极调查中。一个系统的 对所有患者进行随访的方法将使我们能够确定 多种因素(如年龄、准备方案、类型)的贡献 移植、移植后免疫抑制)的风险 观察到毒副作用。此外，预计管理层 将制定处理已查明的并发症的方法，并 调查过了。 3.前瞻性评估慢性移植物抗宿主病 将对慢性移植物抗宿主病患者进行系统评估 出去。将开发一种针对这种情况的分期系统 项目2.第二阶段和第二阶段的患者和临床标本 项目2中描述的III治疗研究将在 门诊部。

The objectives of the Outpatient Facility are: 1. To provide a common resource for Project 1-5 The facilities of the Outpatient Clinic (OPD) are essential for the acquisition of clinical data required to accomplish the aims of the various projects. It is in the OPD that assessments of sustained engraftment, tumors response, acute and chronic GVHD, manifestations of immunodeficiency, post-engraftment infections and other complications of bone marrow transplant are made. As well as clinical evaluations, the OPD provides a means for procuring blood and tissue specimens for multiple investigators. 2. To provide a systematic approach to the evaluation and management of late complications. The incidence and severity of multiple organ toxicities after BMT is under active investigation. A systematic approach to the follow-up of all patients will allow us to determine the contribution of multiple factors (such as age, preparative regimen, type of transplant, post-transplant immunosuppression) to the risk for the toxicities observed. In addition, it is anticipated that management approaches to the complications identified will be developed and investigated. 3. To prospectively evaluate chronic GVHD A systematic evaluation of patients with chronic GVHD will be carried out. A staging system for this condition will be developed as outlined in Project 2. Patients and clinical specimens for Phase II and Phase III therapeutic studies descried in Project 2 will be obtained in the OPD.