SYMPATHETIC NERVE ACTIVITY AND ADIPOSITY IN HUMAN AGING

人类衰老过程中的交感神经活动和肥胖

• 批准号: 2545135
• 负责人: PAMELA P JONES
• 金额: $ 1.68万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2545135
• 关键词: adipose tissue; aging; body composition; neuromuscular function; sympathetic nervous system

The sympathetic nervous system plays an important role in the regulation of metabolic and cardiovascular function. There is a well documented rise in sympathetic nerve activity to skeletal muscle (MSNA) at rest with aging in humans. The general experimental goal of the proposed studies will be to investigate one possible mechanism responsible for this age- related rise in tonic levels of MSNA. The specific aims are to determine: 1) if increases in total body fat (hyrodensitometry), total abdominal and abdominal visceral fat (computed tomography) with age are related to the increase in MSNA (microneurography); 2) if reductions in these same measures of body fat in older humans by caloric restriction are associated with decreases in MSNA; 3) if increases in these levels of body fat in young humans produced by over-feeding are associated with increases in MSNA; and 4) if changes in resting metabolic rate (RMR, open-circuit spirometry) are positively related to changes in MSNA. It is hypothesized that the measures of body fat will be directly related to MSNA and will contribute significantly to the age differences. Furthermore, changes in MSNA and RMR will be directly related to changes in total body, total abdominal, and abdominal visceral fat after the dietary interventions. The results of these studies will provide insight into one mechanism responsible for increased MSNA with age. This is important in light of the growing recognition of the role of the sympathetic nervous system in the physiology and pathophysiology of human aging.

交感神经系统在这种调节中起着重要作用。 新陈代谢和心血管功能。有一个有充分证据的上升 在交感神经活动对骨骼肌(MSNA)休息时 人类的衰老。拟议研究的总体实验目标 将调查导致这个年龄的一种可能的机制- MSNA的紧张性水平也相应升高。具体目标是确定： 1)如果总体脂增加(水分密度法)，总腹部和 腹部内脏脂肪(计算机断层扫描)与年龄相关 MSNA(显微神经学)的增加；2)如果这些相同的减少 通过限制卡路里来衡量老年人体内脂肪的方法是 与MSNA的下降相关；3)如果这些水平的增加 年轻人因过度进食而产生的体脂与 MSNA增加；以及4)如果静息代谢率(RMR， 开路肺活量测定)与MSNA的变化呈正相关。它 假设身体脂肪的测量将直接相关 对MSNA的影响，并将对年龄差异做出重大贡献。 此外，MSNA和RMR的变化将与变化直接相关 在全身、腹部总脂肪和腹部内脏脂肪方面 饮食干预。这些研究的结果将提供洞察力 导致MSNA随年龄增长而增加的一种机制。这是 重要的是，人们日益认识到 交感神经系统在人类生理学和病理生理学中的作用 衰老。