SYMPATHETIC NERVE ACTIVITY AND ADIPOSITY IN HUMAN AGING

人类衰老过程中的交感神经活动和肥胖

• 批准号: 6026899
• 负责人: PAMELA P JONES
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6026899
• 关键词: adipose tissue; aging; body composition; neuromuscular function; sympathetic nervous system

The sympathetic nervous system plays an important role in the regulation of metabolic and cardiovascular function. There is a well documented rise in sympathetic nerve activity to skeletal muscle (MSNA) at rest with aging in humans. The general experimental goal of the proposed studies will be to investigate one possible mechanism responsible for this age- related rise in tonic levels of MSNA. The specific aims are to determine: 1) if increases in total body fat (hyrodensitometry), total abdominal and abdominal visceral fat (computed tomography) with age are related to the increase in MSNA (microneurography); 2) if reductions in these same measures of body fat in older humans by caloric restriction are associated with decreases in MSNA; 3) if increases in these levels of body fat in young humans produced by over-feeding are associated with increases in MSNA; and 4) if changes in resting metabolic rate (RMR, open-circuit spirometry) are positively related to changes in MSNA. It is hypothesized that the measures of body fat will be directly related to MSNA and will contribute significantly to the age differences. Furthermore, changes in MSNA and RMR will be directly related to changes in total body, total abdominal, and abdominal visceral fat after the dietary interventions. The results of these studies will provide insight into one mechanism responsible for increased MSNA with age. This is important in light of the growing recognition of the role of the sympathetic nervous system in the physiology and pathophysiology of human aging.

交感神经系统在调节中起重要作用 代谢和心血管功能。有充分证据表明， 交感神经活动对骨骼肌（MSNA）在休息， 人类的衰老拟议研究的一般实验目标 将是调查一个可能的机制负责这个年龄- MSNA的紧张性水平的相关上升。具体目标是确定： 1)如果增加全身脂肪（hyrodensitometry），总腹部和 腹部内脏脂肪（计算机断层扫描）与年龄有关， MSNA（显微神经造影）增加; 2）如果这些相同的减少 通过热量限制测量老年人的身体脂肪， 与MSNA降低相关; 3）如果这些水平增加， 年轻人过度喂养产生的体脂与 MSNA增加;和4）如果静息代谢率（RMR， 开路肺功能测定）与MSNA的变化呈正相关。它 假设身体脂肪的测量将直接与 MSNA，并将大大有助于年龄差异。 此外，MSNA和RMR的变化将直接关系到 在全身，腹部和腹部内脏脂肪后， 饮食干预。这些研究的结果将提供洞察力 导致MSNA随年龄增长的机制。这是 鉴于人们日益认识到联合国的作用， 交感神经系统在人类生理和病理生理学中的作用 衰老