AGE & SYMPATHETIC METABOLIC CARDIOVASCULAR REGULATION

年龄

• 批准号: 6371946
• 负责人: PAMELA P JONES
• 金额: $ 11.81万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371946
• 关键词: adult human (21+); age difference; aging; baroreflex; bioenergetics; blood glucose; cardiac output; cardiovascular function; clinical research; exercise; geriatrics; heart rate; human old age (65+); human subject; hypotension; insulin; neuroregulation; nutrition of aging; nutrition related tag; oxygen consumption; sympathetic nervous system

The applicant, Pamela P. Jones, Ph.D., is a physiologist currently supported by an Individual National Research Service Award from NIA. Dr. Jones has demonstrated a consistent focus and record of research productivity in the area of autonomic nervous system (ANS) regulation of energy metabolism and cardiovascular function in humans. Her career goal is to develop an independent, extramurally-funded research program in this area as it pertains to gerontology and geriatric medicine. The KO1 Mentored Research Scientist Development Award would provide the opportunity to extend her current research skills to achieve this goal. Career Development/Training Plan. The training plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course- work in research ethics, biostatistics, and gerontology/geriatric medicine; participation in journal clubs and seminar series; regular mentoring interactions; and attendance/presentation at scientific meetings. A team of established senior investigators with expertise in all aspects of the proposed training plan has been formed to mentor Dr. Jones. Research Plan. The central theme of the research project is to determine the role of the ANS in the attenuated increase in energy expenditure (reduced thermic effect of food-TEF) and the fall in arterial blood pressure (postprandial hypotension) associated with feeding in older healthy sedentary humans. A secondary theme will be to determine if older adults who exercise regularly demonstrate a greater TEF and an absence of postprandial hypotension compared to sedentary older adults. Five specific aims have been developed to address these issues. The general hypothesis is that the lower TEF and postprandial hypotension observed in older sedentary adults will be related to an attenuated increase in sympathetic nervous system (SNS) activity. In contrast, physically active older adults will, in comparison, demonstrate a greater TEF, no postprandial hypotension, and an augmented SNS response. The expected results should provide new and clinically useful information concerning the influences of sedentary aging and habitual physical activity on an important component of body weight regulation (TEF) as well as cardiovascular disease risk (postprandial hypotension). Environment. The environment for Dr. Jones training is excellent. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in aging research, and has a well-funded laboratory. He and the host department will provide Dr. Jones all of the necessary resources to successfully complete her training.

申请人Pamela P. Jones博士，目前是一名生理学家 得到 NIA 个人国家研究服务奖的支持。 琼斯博士表现出一贯的专注力和研究记录 自主神经系统 (ANS) 调节领域的生产力 人类能量代谢和心血管功能。 她的事业 目标是开发一个独立的、外部资助的研究项目 在这一领域，因为它涉及老年学和老年医学。 这 KO1 指导研究科学家发展奖将提供 有机会扩展她目前的研究技能以实现这一目标。 职业发展/培训计划。 培训计划包括2 主要要素：1）收购数量惊人的新产品 研究技能； 2）结构化活动，包括正式课程- 研究伦理学、生物统计学和老年学/老年医学领域的工作 药品;参加期刊俱乐部和研讨会系列；常规的 指导互动；以及出席/在科学会议上发表演讲 会议。 一支由具有专业知识的资深研究人员组成的团队 已形成拟议培训计划的各个方面以进行指导 琼斯博士。 研究计划。研究项目的中心主题是确定 ANS 在减弱能量消耗增加中的作用 （食物-TEF 的热效应降低）和动脉血下降 与老年人喂养相关的压力（餐后低血压） 健康的久坐人类。 第二个主题是确定是否 经常锻炼的老年人表现出更高的 TEF 和 与久坐的老年人相比，没有餐后低血压。 为了解决这些问题，制定了五个具体目标。这 一般假设是 TEF 较低和餐后低血压 在久坐的老年人中观察到的情况与减弱的 交感神经系统（SNS）活动增加。 相比之下， 相比之下，身体活跃的老年人将表现出 TEF 更大，无餐后低血压，SNS 反应增强。 预期的结果应该提供新的和临床上有用的 有关久坐衰老和习惯性影响的信息 体力活动是体重调节的重要组成部分 （TEF）以及心血管疾病风险（餐后低血压）。 环境。 琼斯博士的培训环境非常好。 这 发起人 Douglas R. Seals 博士是一位资深的研究者， 衰老研究导师，并拥有资金雄厚的实验室。 他和 主办部门将为琼斯博士提供所有必要的资源 顺利完成她的训练。