AGE & SYMPATHETIC METABOLIC CARDIOVASCULAR REGULATION

申请人帕梅拉·琼斯博士目前是一名生理学家。 由NIA颁发的个人国家研究服务奖支持。 琼斯博士展示了一贯的研究重点和记录 自主神经系统(ANS)调节领域的生产力 人类的能量新陈代谢和心血管功能。她的事业 目标是开发一个独立的、由外部资金资助的研究项目 在这一领域，因为它与老年学和老年医学有关。这个 KO1导师研究科学家发展奖将提供 有机会扩展她目前的研究技能，以实现这一目标。 职业发展/培训计划。培训计划由2个部分组成 主要内容：1)收购数量可观的新产品 研究技能；和2)有组织的活动，包括正式课程- 研究伦理、生物统计学和老年学/老年学方面的工作 医学.参加期刊俱乐部和系列研讨会.常规 指导互动；出席/在科学会议上演讲 开会。一支由具有专业知识的资深调查人员组成的团队 在各方面建议的培训计划都已形成，以指导 琼斯博士。 研究计划。研究项目的中心主题是确定 ANS在减缓能源消耗增加中的作用 (减少食物的热效应-TEF)和动脉血的下降 老年人进食时的血压(餐后低血压) 健康久坐的人类。次要主题将是确定是否 经常锻炼的老年人表现出更大的TEF和 与久坐不动的老年人相比，没有餐后低血压。 为解决这些问题制定了五个具体目标。这个 一般假设是较低的TEF和餐后低血压 在久坐不动的老年人中观察到的与衰弱有关 交感神经系统(SNS)活动增加。相比之下， 相比之下，经常运动的老年人会表现出 更大的TEF，没有餐后低血压，SNS反应增强。 预期的结果应该提供新的和临床有用的 关于久坐老化和习惯的影响的信息 体力活动是调节体重的重要组成部分 (TEF)以及心血管疾病风险(餐后低血压)。 环境琼斯博士培训的环境非常好。这个 赞助商道格拉斯·R·西尔斯博士是一名知名的研究人员， 在衰老研究方面担任导师，并拥有资金雄厚的实验室。他和他的 主办部门将为琼斯博士提供所有必要的资源 才能顺利完成她的训练。

The applicant, Pamela P. Jones, Ph.D., is a physiologist currently supported by an Individual National Research Service Award from NIA. Dr. Jones has demonstrated a consistent focus and record of research productivity in the area of autonomic nervous system (ANS) regulation of energy metabolism and cardiovascular function in humans. Her career goal is to develop an independent, extramurally-funded research program in this area as it pertains to gerontology and geriatric medicine. The KO1 Mentored Research Scientist Development Award would provide the opportunity to extend her current research skills to achieve this goal. Career Development/Training Plan. The training plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course- work in research ethics, biostatistics, and gerontology/geriatric medicine; participation in journal clubs and seminar series; regular mentoring interactions; and attendance/presentation at scientific meetings. A team of established senior investigators with expertise in all aspects of the proposed training plan has been formed to mentor Dr. Jones. Research Plan. The central theme of the research project is to determine the role of the ANS in the attenuated increase in energy expenditure (reduced thermic effect of food-TEF) and the fall in arterial blood pressure (postprandial hypotension) associated with feeding in older healthy sedentary humans. A secondary theme will be to determine if older adults who exercise regularly demonstrate a greater TEF and an absence of postprandial hypotension compared to sedentary older adults. Five specific aims have been developed to address these issues. The general hypothesis is that the lower TEF and postprandial hypotension observed in older sedentary adults will be related to an attenuated increase in sympathetic nervous system (SNS) activity. In contrast, physically active older adults will, in comparison, demonstrate a greater TEF, no postprandial hypotension, and an augmented SNS response. The expected results should provide new and clinically useful information concerning the influences of sedentary aging and habitual physical activity on an important component of body weight regulation (TEF) as well as cardiovascular disease risk (postprandial hypotension). Environment. The environment for Dr. Jones training is excellent. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in aging research, and has a well-funded laboratory. He and the host department will provide Dr. Jones all of the necessary resources to successfully complete her training.