AGE & SYMPATHETIC METABOLIC CARDIOVASCULAR REGULATION

申请人帕梅拉·琼斯博士目前是一名生理学家 由NIA的个人国家研究服务奖支持。 博士琼斯表现出了一贯的重点和研究记录 自主神经系统（ANS）调节领域的生产力 能量代谢和心血管功能。 她的职业生涯 目标是发展一个独立的，由校外资助的研究项目 在这一领域，因为它涉及老年学和老年医学。 的 KO 1指导研究科学家发展奖将提供 有机会扩展她目前的研究技能，以实现这一目标。 职业发展/培训计划。 培训计划包括2 主要内容：1）收购大量新的 研究技能; 2）有组织的活动，包括正式课程- 研究伦理学、生物统计学和老年学/老年医学方面的工作 医学;参加期刊俱乐部和系列研讨会;定期 指导互动;以及出席科学会议/在会上发言 会议. 一个由具有专门知识的资深调查员组成的小组 在各方面的建议培训计划已形成导师 博士琼斯 研究计划。该研究项目的中心主题是确定 ANS在能量消耗减弱增加中的作用 （减少食物的热效应-TEF）和动脉血中的下降 老年人与进食相关的血压（餐后低血压） 健康久坐的人类 第二个主题是确定 经常锻炼的老年人表现出更大的TEF和更高的 与久坐的老年人相比，无餐后低血压。 为解决这些问题制定了五项具体目标。的 一般的假设是，较低的TEF和餐后低血压 在久坐的老年人中观察到的， 交感神经系统（SNS）活动增加。 与此相反， 相比之下，身体活跃的老年人将表现出 TEF更高，无餐后低血压，SNS反应增强。 预期的结果应提供新的和临床上有用的 关于久坐不动的老化和习惯性 体力活动是调节体重的重要组成部分 (TEF)以及心血管疾病风险（餐后低血压）。 环境 琼斯博士的训练环境非常好。 的 赞助商，道格拉斯R。Seals博士，是一个既定的调查员， 他是老龄化研究的导师，并拥有一个资金充足的实验室。 他和 接待部门将为琼斯博士提供所有必要的资源 顺利完成训练

The applicant, Pamela P. Jones, Ph.D., is a physiologist currently supported by an Individual National Research Service Award from NIA. Dr. Jones has demonstrated a consistent focus and record of research productivity in the area of autonomic nervous system (ANS) regulation of energy metabolism and cardiovascular function in humans. Her career goal is to develop an independent, extramurally-funded research program in this area as it pertains to gerontology and geriatric medicine. The KO1 Mentored Research Scientist Development Award would provide the opportunity to extend her current research skills to achieve this goal. Career Development/Training Plan. The training plan consists of 2 primary elements: 1) the acquisition of an impressive number of new research skills; and 2) structured activities including formal course- work in research ethics, biostatistics, and gerontology/geriatric medicine; participation in journal clubs and seminar series; regular mentoring interactions; and attendance/presentation at scientific meetings. A team of established senior investigators with expertise in all aspects of the proposed training plan has been formed to mentor Dr. Jones. Research Plan. The central theme of the research project is to determine the role of the ANS in the attenuated increase in energy expenditure (reduced thermic effect of food-TEF) and the fall in arterial blood pressure (postprandial hypotension) associated with feeding in older healthy sedentary humans. A secondary theme will be to determine if older adults who exercise regularly demonstrate a greater TEF and an absence of postprandial hypotension compared to sedentary older adults. Five specific aims have been developed to address these issues. The general hypothesis is that the lower TEF and postprandial hypotension observed in older sedentary adults will be related to an attenuated increase in sympathetic nervous system (SNS) activity. In contrast, physically active older adults will, in comparison, demonstrate a greater TEF, no postprandial hypotension, and an augmented SNS response. The expected results should provide new and clinically useful information concerning the influences of sedentary aging and habitual physical activity on an important component of body weight regulation (TEF) as well as cardiovascular disease risk (postprandial hypotension). Environment. The environment for Dr. Jones training is excellent. The sponsor, Douglas R. Seals, Ph.D., is an established investigator and mentor in aging research, and has a well-funded laboratory. He and the host department will provide Dr. Jones all of the necessary resources to successfully complete her training.