OPTIMAL DESIGN OF THA RANDOM LOAD AND BONE VARIATION

随机载荷和骨变化的优化设计

• 批准号: 2429592
• 负责人: DONALD L. BARTEL
• 金额: $ 12.25万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-10 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2429592
• 关键词: biomechanics; computer data analysis; computer program /software; gait; hip prosthesis; mechanical stress; model design /development; physical model; physiologic bone resorption; skeletal prosthesis; technology /technique development

DESCRIPTION (Adapted from investigator's abstract): The overall goal of the proposed project is to optimize bone-implant systems while taking into account statistical distributions in environmental variables, such as loading on the prosthesis and bone tissue properties adjacent to the prosthesis. To date, optimal designs of implants have not considered the effects of observed variations in loading and bone properties that occur from individual to individual, and in a single individual over time. If conventional search techniques are used, the optimal design of total joint replacements is computationally expensive, particularly if variation in the loading and material property distributions are included. If the effects of bone remodeling and in vivo changes in implant materials and interfaces are included, the computational demands are even greater. Therefore, new methods must be employed. The primary goal of the proposed research is to establish and validate general methodology for evaluating the optimal design of orthopaedic systems that involve large-scale, nonlinear computational analyses. As a secondary goal, and as an example of the usefulness of the methodology, the robustness of optimal designs of uncemented femoral components for total hip replacements will be determined, taking into account environmental variations in loading and bone properties. Specifically, the applicants will determine the strategy in statistical methodology for designing computer experiments that will maximize the efficiency of these methods for the optimal design of total joint replacements. They will first validate these methods using in vitro experiments. They will then apply these methods to determine the design of an anatomical femoral component for a total hip replacement that minimizes the load bypass (stress shielding) in the proximal femur for distributions to the prosthesis. Finally, they will use the methodology to determine the robustness of the optimal designs for more strenuous loading conditions than those that occur during gait, and for bone properties that are substantially different from those that occur in the normal population due to aging or disease.

描述（改编自研究者摘要）： 拟议的项目是优化骨植入系统，同时考虑到 考虑环境变量的统计分布，例如 假体上的载荷和假体附近的骨组织特性 假肢 迄今为止，植入物的最佳设计尚未考虑到 观察到的载荷和骨特性变化的影响， 从一个个体到另一个个体，以及在一个个体中随着时间的推移。 如果 采用传统的搜索技术， 替换在计算上是昂贵的，特别是如果 包括载荷和材料特性分布。 如果影响 骨重建和植入材料和界面的体内变化， 包括在内，计算需求甚至更大。 因此，新 方法必须使用。 拟议研究的主要目标是建立和验证 评价矫形系统最佳设计的一般方法 涉及大规模的非线性计算分析。 作为次要 目标，并作为该方法的有用性的例子，鲁棒性 全髋关节非骨水泥型股骨假体的优化设计 将在考虑环境因素的情况下确定替代品 载荷和骨特性的变化。 具体而言，申请人 将决定统计方法的战略， 计算机实验，将最大限度地提高这些方法的效率， 全关节置换的优化设计。 他们将首先验证 这些方法使用体外实验。 然后，他们将应用这些 用于确定解剖股骨部件设计的方法 全髋关节置换术，最大限度地减少负荷旁路（应力屏蔽）， 股骨近端用于假体分配。 最后，他们会 使用该方法确定最佳设计的稳健性， 比步态期间发生的更剧烈的负荷条件， 骨特性与发生在 由于衰老或疾病而导致的正常人群。