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OPTIMAL DESIGN OF THA RANDOM LOAD AND BONE VARIATION

随机载荷和骨变化的优化设计

基本信息

批准号：
2712453
负责人：
DONALD L. BARTEL
金额：
$ 12.53万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-06-10 至 2000-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2712453
关键词：
biomechanics computer data analysis computer program /software gait hip prosthesis mechanical stress model design /development physical model physiologic bone resorption skeletal prosthesis technology /technique development

项目摘要

DESCRIPTION (Adapted from investigator's abstract): The overall goal of the proposed project is to optimize bone-implant systems while taking into account statistical distributions in environmental variables, such as loading on the prosthesis and bone tissue properties adjacent to the prosthesis. To date, optimal designs of implants have not considered the effects of observed variations in loading and bone properties that occur from individual to individual, and in a single individual over time. If conventional search techniques are used, the optimal design of total joint replacements is computationally expensive, particularly if variation in the loading and material property distributions are included. If the effects of bone remodeling and in vivo changes in implant materials and interfaces are included, the computational demands are even greater. Therefore, new methods must be employed. The primary goal of the proposed research is to establish and validate general methodology for evaluating the optimal design of orthopaedic systems that involve large-scale, nonlinear computational analyses. As a secondary goal, and as an example of the usefulness of the methodology, the robustness of optimal designs of uncemented femoral components for total hip replacements will be determined, taking into account environmental variations in loading and bone properties. Specifically, the applicants will determine the strategy in statistical methodology for designing computer experiments that will maximize the efficiency of these methods for the optimal design of total joint replacements. They will first validate these methods using in vitro experiments. They will then apply these methods to determine the design of an anatomical femoral component for a total hip replacement that minimizes the load bypass (stress shielding) in the proximal femur for distributions to the prosthesis. Finally, they will use the methodology to determine the robustness of the optimal designs for more strenuous loading conditions than those that occur during gait, and for bone properties that are substantially different from those that occur in the normal population due to aging or disease.

说明(改编自调查员摘要)：拟议的项目是优化骨植入系统，同时考虑到计算环境变量的统计分布，例如假体的负荷和邻近的骨组织特性假肢。到目前为止，植入物的优化设计还没有考虑到观察到的载荷和骨性能变化的影响从一个人到另一个人，随着时间的推移，在一个人身上。如果采用常规搜索技术，对总节点进行了优化设计替换在计算上是昂贵的，特别是如果其中包括载荷和材料特性分布。如果这一影响植入材料和界面中的骨重塑和体内变化包括在内，计算需求甚至更大。因此，新的必须采用方法。拟议研究的主要目标是建立和验证评价矫形外科系统最优设计的一般方法这涉及大规模的、非线性的计算分析。作为次要角色目标，作为方法论有用性的一个例子，稳健性非骨水泥型全髋关节假体的优化设计将考虑环境因素来确定替换方案负荷和骨骼特性的变化。具体地说，申请人将在统计方法论中确定策略进行设计计算机实验将使这些方法的效率最大化关节整体置换的优化设计。他们将首先验证这些方法使用的是体外实验。然后，他们将应用这些确定解剖型股骨假体设计的方法全髋关节置换术，最大限度地减少负荷旁路(应力遮挡) 股骨近端用于假体的分布。最后，他们会使用方法论确定最优设计的稳健性比在步态中发生的更剧烈的负荷条件，以及骨的特性与那些发生在由于衰老或疾病而导致的正常人群。