PHYTOESTROGENS AND BREAST CANCER PREVENTION

在与癌症作了20年的战斗之后，医生和公众 卫生专家现在意识到，必须在以下方面投入更多努力 预防。外行人也意识到了这一点。美国人花费了8200万美元 每年只服用一种被认为可以预防癌症的化合物(β-胡萝卜素)。 这种饮食是潜在的化学预防化合物的丰富来源。 流行病学研究表明，大量消费的人群 摄入大量大豆的人患乳腺癌、结肠癌和前列腺癌的几率比食用大豆少。 美国人。动物实验已证实其抗癌作用。 大豆。大豆含有许多抗癌剂，包括 异黄酮类、大豆苷和染料木苷。这项研究考察了潜在的 植物雌激素降低乳腺癌的机制。 需要检验的假设是，食用含有豆奶的 植物雌激素可减少循环中的卵巢类固醇和促性腺激素。 这样的变化可能是肿瘤保护性的。绝经前妇女有规律的 月经周期(20-30岁)和不服用避孕药 饲喂含大豆饲料1个月。他们的荷尔蒙水平会 在大豆饲喂前测量3个月，在大豆饲喂1个月期间测量 饲喂和停用大豆饲料后至少5个月。这个 受试者摄入0-100毫克大豆苷元和0-100毫克染料木素 (大豆中的两种植物雌激素)每天在临床研究中心。 这项研究将确定所需的植物雌激素消耗量。 目的：减少绝经前妇女的卵巢类固醇和促性腺激素。在……里面 另一项研究显示，绝经后妇女将摄入豆奶4个月 并为患者提供血液、尿液、阴道涂片和子宫内膜活检 类固醇，异黄酮代谢物，细胞学和组织学的分析， 分别进行了分析。这些妇女还将接受子宫内膜厚度的检查。 通过阴道探头超声检查。这些研究将确定雌激素性 长期食用植物雌激素。将使用已建立的免疫分析方法 来分析荷尔蒙水平。这项研究将具有重要的意义 为了美国妇女的健康和美国的经济，这是 一个主要的大豆生产国。

After two decades of fighting the "War on Cancer," physicians and public health specialists now realize that more effort must be devoted to prevention. Lay persons realize this, also. Americans spent $82 million per year on just one compound thought to prevent cancer (beta-carotene). The diet is a bountiful source of potentially chemopreventive compounds. Epidemiological studies have shown that populations consuming large amounts of soybeans have less breast, colon, and prostate cancer than do Americans. Animal studies have confirmed the cancer protective effect of soybeans. Soybeans contain numerous anticancer agents, including the isoflavones, daidzin and genistin. This study examines underlying mechanisms responsible for breast cancer reduction by phytoestrogens. The hypothesis to be tested is that consumption of soymilk containing phytoestrogens reduces circulating ovarian steroids and gonadotropins. Such changes may be oncoprotective. Premenopausal women with regular menstrual cycle (20-30 years old) and not on birth control pills will be placed on soybean containing diet for 1 month. Their hormone levels will be measured for 3 months before soya feeding, during 1 month of soya feeding and for at least 5 months after withdrawal from soya feeding. The subjects will consume 0 - 100 mg of daidzein and 0 - 100 mg of genistein (the two phytoestrogens in soybeans) daily on a Clinical Research Center. This study will determine the quantity of phytoestrogen consumption needed to reduce ovarian steroids and gonadotropins in premenopausal women. In separate studies, postmenopausal women will ingest soymilk for 4 months and provide blood, urine, vaginal smears, and endometrial biopsies for the analyses of steroids, isoflavone metabolites, cytology, and histology, respectively. These women will also be examined for endometrial thickness by vaginal probe ultrasound. These studies will determine estrogenicity of long term phytoestrogen consumption. Established immunoassays will be used to analyze hormone levels. This study will have significant implications for the health of American women and for the economy of the U.S., which is a major soybean producer.