PHYTOESTROGENS AND BREAST CANCER PREVENTION

植物雌激素和乳腺癌预防

• 批准号: 2443121
• 负责人: LEE-JANE W LU
• 金额: $ 25.82万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443121
• 关键词: alternative medicine; biopsy; breast neoplasms; cancer prevention; cervical /vaginal smear; chemoprevention; clinical chemistry; clinical research; cytology; diet therapy; dietary supplements; drug metabolism; endometrium; estrogens; female; flavones; genistein; hormone regulation /control mechanism; human subject; human therapy evaluation; longitudinal human study; nutrient interaction; nutrition aspect of cancer; nutrition related tag; postmenopause; soybeans

After two decades of fighting the "War on Cancer," physicians and public health specialists now realize that more effort must be devoted to prevention. Lay persons realize this, also. Americans spent $82 million per year on just one compound thought to prevent cancer (beta-carotene). The diet is a bountiful source of potentially chemopreventive compounds. Epidemiological studies have shown that populations consuming large amounts of soybeans have less breast, colon, and prostate cancer than do Americans. Animal studies have confirmed the cancer protective effect of soybeans. Soybeans contain numerous anticancer agents, including the isoflavones, daidzin and genistin. This study examines underlying mechanisms responsible for breast cancer reduction by phytoestrogens. The hypothesis to be tested is that consumption of soymilk containing phytoestrogens reduces circulating ovarian steroids and gonadotropins. Such changes may be oncoprotective. Premenopausal women with regular menstrual cycle (20-30 years old) and not on birth control pills will be placed on soybean containing diet for 1 month. Their hormone levels will be measured for 3 months before soya feeding, during 1 month of soya feeding and for at least 5 months after withdrawal from soya feeding. The subjects will consume 0 - 100 mg of daidzein and 0 - 100 mg of genistein (the two phytoestrogens in soybeans) daily on a Clinical Research Center. This study will determine the quantity of phytoestrogen consumption needed to reduce ovarian steroids and gonadotropins in premenopausal women. In separate studies, postmenopausal women will ingest soymilk for 4 months and provide blood, urine, vaginal smears, and endometrial biopsies for the analyses of steroids, isoflavone metabolites, cytology, and histology, respectively. These women will also be examined for endometrial thickness by vaginal probe ultrasound. These studies will determine estrogenicity of long term phytoestrogen consumption. Established immunoassays will be used to analyze hormone levels. This study will have significant implications for the health of American women and for the economy of the U.S., which is a major soybean producer.

经过二十年的“抗癌战争”，医生和公众 卫生专家现在认识到，必须投入更多的努力， 预防外行人也意识到了这一点。美国人花了8200万美元 每年只服用一种被认为可以预防癌症的化合物（β-胡萝卜素）。 饮食是潜在的化学预防化合物的邦蒂富尔来源。 流行病学研究表明， 大量的大豆比大豆更少患乳腺癌、结肠癌和前列腺癌。 美国人动物研究已经证实， 大豆蚕豆含有许多抗癌剂，包括 甘草酮，大豆苷和染料木苷。这项研究探讨了潜在的 植物雌激素减少乳腺癌的机制。 待检验的假设是， 植物雌激素减少循环卵巢类固醇和促性腺激素。 这种变化可能是肿瘤保护性的。绝经前妇女定期 月经周期（20-30岁），而不是避孕药将 放置在含大豆的饮食中1个月。他们的荷尔蒙水平 在饲喂大豆前3个月，在饲喂大豆的1个月期间， 喂养和停止大豆喂养后至少5个月。的 受试者将消耗0 - 100 mg大豆苷元和0 - 100 mg染料木黄酮 (the大豆中的两种植物雌激素）。 这项研究将确定所需的植物雌激素消费量 减少绝经前妇女的卵巢类固醇和促性腺激素。在 另一项研究表明，绝经后妇女将摄入豆浆4个月， 并提供血液，尿液，阴道涂片和子宫内膜活检， 类固醇代谢物细胞学和组织学分析， 分别这些妇女还将检查子宫内膜厚度 阴道探头超声波检查这些研究将确定 长期食用植物雌激素。将使用已建立的免疫测定法 来分析荷尔蒙水平这项研究将产生重大影响 为了美国妇女的健康和美国的经济，这是 一个主要的大豆生产商。