INTERGROUP CPRU--FDR SCREENING 3 COLORECTAL CA++ SITES

INTERGROUP CPRU--FDR 筛查 3 个结直肠 CA 部位

• 批准号: 2443171
• 负责人: DENNIS J AHNEN
• 金额: $ 13.89万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443171
• 关键词: breast neoplasms; cancer prevention; cancer risk; colorectal neoplasms; counseling; education evaluation /planning; family genetics; human middle age (35-64); human subject; interview; mass screening; neoplasm /cancer education; neoplasm /cancer genetics

This proposal is one of 3 interactive R0I applications being submitted in response to RFA CA-94-009: Collaborative Cancer Prevention Research Units. The overall goal of the proposed CPRU is to design, implement, and evaluate a standardized, telephone-based, education and counseling intervention to promote appropriate cancer screening practices among first degree relatives of cancer patients. This component of the CPRU application targets colorectal cancer screening among age-eligible (greater than 40 years old) first degree relatives of colorectal cancer patients. The specific aims of the proposal are 1. to finalize the design of a theory-driven (Transtheoretical Model of Behavioral Change, the Health Beliefs Model and the Transactional Model of Stress), telephone- based, counseling/educational intervention combined with a reinforcement mailout; 2. to validate a colorectal cancer screening self-report instrument in a pilot case-control study; 3. to pilot test the intervention in 2 Denver-based medical centers; 4. to implement the revised intervention by identification of patients with colon cancer within 10 participating centers affiliated with 3 of the largest clinical cooperative groups in the U.S. (ECOG, SWOG and NCCTG); the telephone interviews and the intervention in the first degree relatives will be performed by a team of highly trained telephone counselors from a Telephone Counseling and Survey Methods Shared Resource of the CPRU; 5. to evaluate the intervention using a randomized 2- group design (intervention vs control) with the family unit as the unit of randomization and a 3 month and 1-year follow up to assess both short- term (changes in health beliefs, psychologic impact) and long-term outcomes (rates of colorectal cancer screening); and 6. to conduct comparative analyses, using a Data Management and Biostastistical Shared Resource, across all components of the CPRU to assess the generalizability of the intervention across cancer sites, screening modalities and gender. This CPRU application with its cadre of investigators and its network of participating SWOG , ECOG, and NCCTG centers also forms the infrastructure for a powerful ongoing program of Cancer Prevention and Control Research.

此提案是提交的3个交互式R 0 I应用程序之一 针对RFA CA-94-009：癌症预防合作研究 单位建议的CPRU的总体目标是设计，实施， 评估一个标准化的，基于电话的，教育和咨询 采取干预措施，促进适当的癌症筛查做法， 癌症患者的一级亲属。 CPRU的这一组成部分 应用目标是在符合年龄条件的人群中进行结直肠癌筛查 （40岁以上）结直肠癌一级亲属 患者该提案的具体目标是1。完成设计 行为改变的跨理论模型（Transtheoretical Model of Behavioral Change） 健康信念模型和压力的跨文化模型），电话- 基于咨询/教育干预与强化相结合 邮件; 2.验证结直肠癌筛查自我报告 初步病例对照研究中的仪器; 3.进行试点测试， 在丹佛的2个医疗中心进行干预; 4.实施 通过识别结肠癌患者进行修订干预 在隶属于3个最大临床试验机构的10个参与中心内， 美国的合作团体（ECOG，SWOG和NCCTG）;电话 采访和干预的一级亲属将是 由一组训练有素的电话咨询师从一个 五、电话谘询及问卷调查方法之研究。 采用随机2组设计评价干预措施 （干预与控制）以家庭为单位， 随机分组，并进行3个月和1年随访，以评估短期- 长期（健康信念的变化，心理影响）和长期 结果（结直肠癌筛查率）;以及6.进行 比较分析，使用数据管理和生物统计共享 资源，跨CPRU的所有组成部分，以评估 干预在癌症部位的普遍性，筛查 方式和性别。 这个CPRU应用程序及其调查人员的骨干和网络， 参与的SWOG、ECOG和NCCTG中心也构成了 一个强大的正在进行的癌症预防计划的基础设施， 控制研究。