INTERGROUP CPRU--FDR SCREENING 3 COLORECTAL CA++ SITES

这份建议书是正在提交的3个交互式R0I申请之一 响应RFA CA-94-009：协作性癌症预防研究 单位。建议的CPRU的总体目标是设计、实施和 评估标准化的、基于电话的教育和咨询 采取干预措施促进适当的癌症筛查做法 癌症患者的一级亲属。CPRU的此组件 在符合年龄条件的人群中应用结直肠癌筛查 (40岁以上)结直肠癌的一级亲属 病人。该提案的具体目标是：1.完成设计 理论驱动的(行为改变的跨理论模型，The 健康信念模型和压力的交易模型)、电话- 以此为基础的咨询/教育干预与强化相结合 邮寄；2.验证结直肠癌筛查自我报告 试验性病例对照研究中的仪器；3.试验性试验 在丹佛的2个医疗中心进行干预；4.实施 结肠癌患者身份识别的改良干预 在10个参与中心内，隶属于3个最大的临床中心 美国的合作团体(ECOG、SWOG和NCCTG)；电话 面谈和一级亲属的干预将是 由一支训练有素的电话咨询师团队执行 CPRU的电话咨询和调查方法共享资源； 使用随机两组设计评估干预措施 (干预与控制)以家庭为单位 随机化和3个月和1年的随访，以评估短期和 长期(健康信念的变化、心理影响)和长期 结果(结直肠癌筛查率)；和6.进行 比较分析，使用数据管理和生物统计共享 资源，以评估CPRU的所有组件 跨癌症部位、筛查的干预措施的概括性 形态和性别。 这个CPRU应用程序及其调查人员和它的网络 SWOG、ECOG和NCCTG参与中心也组成了 为正在进行的强大的癌症预防和治疗计划提供基础设施 控制研究。

This proposal is one of 3 interactive R0I applications being submitted in response to RFA CA-94-009: Collaborative Cancer Prevention Research Units. The overall goal of the proposed CPRU is to design, implement, and evaluate a standardized, telephone-based, education and counseling intervention to promote appropriate cancer screening practices among first degree relatives of cancer patients. This component of the CPRU application targets colorectal cancer screening among age-eligible (greater than 40 years old) first degree relatives of colorectal cancer patients. The specific aims of the proposal are 1. to finalize the design of a theory-driven (Transtheoretical Model of Behavioral Change, the Health Beliefs Model and the Transactional Model of Stress), telephone- based, counseling/educational intervention combined with a reinforcement mailout; 2. to validate a colorectal cancer screening self-report instrument in a pilot case-control study; 3. to pilot test the intervention in 2 Denver-based medical centers; 4. to implement the revised intervention by identification of patients with colon cancer within 10 participating centers affiliated with 3 of the largest clinical cooperative groups in the U.S. (ECOG, SWOG and NCCTG); the telephone interviews and the intervention in the first degree relatives will be performed by a team of highly trained telephone counselors from a Telephone Counseling and Survey Methods Shared Resource of the CPRU; 5. to evaluate the intervention using a randomized 2- group design (intervention vs control) with the family unit as the unit of randomization and a 3 month and 1-year follow up to assess both short- term (changes in health beliefs, psychologic impact) and long-term outcomes (rates of colorectal cancer screening); and 6. to conduct comparative analyses, using a Data Management and Biostastistical Shared Resource, across all components of the CPRU to assess the generalizability of the intervention across cancer sites, screening modalities and gender. This CPRU application with its cadre of investigators and its network of participating SWOG , ECOG, and NCCTG centers also forms the infrastructure for a powerful ongoing program of Cancer Prevention and Control Research.