Tangent Reprofiling - Combination therapies for hormone-dependent cancers. Utilising an innovative therapeutic strategy of drugs and nutritional supplements. Treating Prostate (and Ovarian, Breast and Endometrial) cancers beyond castration resistance.

Tangent Reprofiling - 激素依赖性癌症的联合疗法。

基本信息

  • 批准号:
    710081
  • 负责人:
  • 金额:
    $ 12.74万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    GRD Proof of Concept
  • 财政年份:
    2012
  • 资助国家:
    英国
  • 起止时间:
    2012 至 无数据
  • 项目状态:
    已结题

项目摘要

Some cancerous tumors require, or grow faster in the presence of, steroid hormones such as estrogen or testosterone. These cancers can be treated by chemotherapy drugs to prevent the tumor using hormones found naturally in the body. Many of these drugs work by blocking the receptors for the hormone on the outside edges of the tumor, starving the tumor by preventing it from recognizing the hormone. However, many hormone-dependant tumors develop resistance to these drugs by learning to make the hormones internally.We used our proprietary technology to study drugs that are currently used in non-cancerdiseases. One drug was identified as being capable of preventing internal hormone production by tumors. This drug is already in clinical use for an alternative disease which requires long term use, so the safety and side effects are already well characterized across a broad population of patients. We propose combining this drug with current chemotherapy regimes to attack the tumor from within while maintaining the starvation procedure described above.We already have data to demonstrate a reduction in growth of prostate cancer cells with the drug in vitro, however, we now need to expand this to look at additional combinations of drugs; to look at additional cancer cell types; and to test the final drug combinations in animal models.As well as combining our drug with current chemotherapies, we will test it in combination with omega-3 fatty acids. These are popular nutritional supplements, and have been proposed to have therapeutic effect in some cancers. This supplement should work in concert with our drug to provide additional benefit. There are several forms of omega-3 fatty acids, so we need to identify the best and then look for the ideal ratio of our drug and the supplement.We believe this offers an exciting opportunity to prolong successful treatment of a range of common cancers including prostate, endometrial, breast and ovarian cancer.
一些癌性肿瘤需要类固醇激素(例如雌激素或睾酮),或者在类固醇激素存在下生长得更快。这些癌症可以通过化疗药物治疗,以利用体内天然存在的激素来预防肿瘤。许多这些药物的作用是阻断肿瘤外缘的激素受体,通过阻止肿瘤识别激素来使肿瘤挨饿。然而,许多激素依赖性肿瘤通过学习在内部制造激素而对这些药物产生耐药性。我们使用我们的专有技术来研究目前用于非癌症疾病的药物。一种药物被认为能够阻止肿瘤产生内部激素。该药物已经在临床上用于治疗需要长期使用的替代疾病,因此其安全性和副作用已经在广大患者群体中得到了很好的表征。我们建议将该药物与当前的化疗方案相结合,从内部攻击肿瘤,同时维持上述的饥饿程序。我们已经有数据证明该药物在体外可减少前列腺癌细胞的生长,但是,我们现在需要扩展这一点以研究其他药物组合;查看其他癌细胞类型;并在动物模型中测试最终的药物组合。除了将我们的药物与当前的化疗相结合外,我们还将测试它与 omega-3 脂肪酸的组合。这些是流行的营养补充剂,并且已被认为对某些癌症具有治疗作用。这种补充剂应与我们的药物协同作用,以提供额外的益处。 omega-3 脂肪酸有多种形式,因此我们需要确定最佳形式,然后寻找我们的药物和补充剂的理想比例。我们相信,这为延长一系列常见癌症(包括前列腺癌、子宫内膜癌、乳腺癌和卵巢癌)的成功治疗提供了令人兴奋的机会。

项目成果

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其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

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{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
  • 批准号:
    2908918
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
    2908693
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Studentship

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Tangent Reprofiling. Development of prototype: TAN2004, a safe, known drug formulated for treatment of prostate and lung cancer.
切线重新轮廓分析。
  • 批准号:
    720370
  • 财政年份:
    2014
  • 资助金额:
    $ 12.74万
  • 项目类别:
    GRD Development of Prototype
Development of the antiparkinsonian drug with novel mechanism by drug-reprofiling.
通过药物重新分析开发具有新机制的抗帕金森病药物。
  • 批准号:
    25460204
  • 财政年份:
    2013
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Exploiting data for drug reprofiling
利用数据进行药物重新分析
  • 批准号:
    100922
  • 财政年份:
    2011
  • 资助金额:
    $ 12.74万
  • 项目类别:
    Collaborative R&D
ABLATABLE MASK FOR LASER REPROFILING OF THE CORNEA
用于角膜激光重建的可烧蚀面罩
  • 批准号:
    3497215
  • 财政年份:
    1992
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