LONGITUDINAL QUALITY OF LIFE AFTER MARROW TRANSPLANT

骨髓移植后的纵向生活质量

• 批准号: 2390934
• 负责人: Gary W. Donaldson
• 金额: $ 22.8万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2390934
• 关键词: behavioral /social science research tag; bone marrow transplantation; clinical research; functional ability; human data; human subject; human therapy evaluation; longitudinal human study; mathematical model; medical complication; method development; psychometrics; quality of life; questionnaires; statistical service /center

DESCRIPTION: This project will use improved methods of longitudinal analysis to evaluate the multidimensional course of quality of life (QOL) in the four years following bone marrow transplantation (BMT), providing better descriptions of how QOL changes following BMT, thereby allowing patients to make more informed choices among competing treatments. The increased precision and accuracy offered by these methods may enable clinicians to intervene prospectively to minimize complications and smooth the path to recovery. The new methods for longitudinal evaluation are general, and will extend to other cancer populations. Building on an existing survey of 125 extreme (6 18 years) long term survivors and on extensive pilot work with new one year survivors, approximately 150 new patients will be recruited each year (600 total) for QOL assessments at 6 month intervals over four years, yielding a much larger longitudinal BMT sample than any previously studied. The questionnaire battery assesses functioning in the physical, role, emotional, cognitive, and social domains, and includes general psychometric assessments of affective and health perceptions. In addition, the battery includes BMT specific inventories, developed by project personnel, assessing late medical complications and demands imposed by recovery. Participating patients will complete all questionnaires in their residences, receiving and returning the packets by mail. The new longitudinal data collected for this project will enhance psychometric development by a (a) developing a briefer form of existing instruments amenable to more frequent administration, and (b) using structural equation modeling techniques to establish and improve the sensitivity to change of key indicators in the battery. Because of the large projected sample, standard longitudinal analyses will precisely describe the expected quality of life for patients conditional on survival to each assessment. Surviving subsamples, however, may selectively overestimate expected trends for the general population of new patients; thus a major focus of this study is the development of unconditional estimates of QOL trends that are not subject to this attrition bias. To obtain unconditional estimates of quality of life trends, the authors will a) employ mixed effects models as discussed by Donaldson; and b) develop endpoints, formally similar to Q TWIST, that use psychometric norms to weight survival times for QOL experienced during BMT recovery.

描述：该项目将使用改进的纵向方法 analysis to evaluate the multidimensional course of quality of life 骨髓移植 (BMT) 后四年内的生活质量 (QOL)， 更好地描述 BMT 之后 QOL 如何变化，从而 让患者在竞争中做出更明智的选择 治疗。这些方法提高了精度和准确度 可能使临床医生能够前瞻性地进行干预，以尽量减少 并发症并顺利康复。新方法用于 纵向评估是一般性的，并将扩展到其他癌症 人口。 以现有的 125 个极端（6-18 年）长期调查为基础 幸存者以及与新一年幸存者进行的广泛试点工作， 每年将招募约 150 名新患者（总共 600 名） 四年内每 6 个月进行一次 QOL 评估，得出 纵向 BMT 样本比之前研究的样本大得多。这 问卷电池评估身体、角色、 情感、认知和社交领域，包括一般 情感和健康认知的心理测量评估。在 此外，该电池还包括 BMT 特定库存，由 项目人员，评估晚期医疗并发症和需求 恢复所施加的。参与的患者将完成所有 到住处问卷调查、领取和返还包裹 通过邮件。 为该项目收集的新纵向数据将增强 心理测量的发展，通过 (a) 开发现有的更简短的形式 适合更频繁管理的工具，以及（b）使用 结构方程建模技术建立和改进 对电池关键指标变化的敏感性。因为 大型投影样本，标准纵向分析将精确 描述患者的预期生活质量，条件是 每次评估的生存率。然而，幸存的子样本可能 有选择地高估一般人群的预期趋势 新患者；因此，本研究的一个主要重点是开发 对不受此限制的 QOL 趋势的无条件估计 磨损偏差。 获得对生活质量的无条件估计 trends, the authors will a) employ mixed effects models as discussed by 唐纳森； b) 开发端点，形式上类似于 Q TWIST，即 使用心理测量标准来衡量经历过的生活质量的生存时间 BMT 恢复期间。