The Time Distribution Method for Measuring Clinically Valid Quality of Life State

测量临床有效生活质量状态的时间分布法

• 批准号: 7842664
• 负责人: Gary W. Donaldson
• 金额: $ 25.57万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842664
• 关键词: Affect; Area; Behavioral Research; Cancer Control; Caring; Categories; Climacteric; Clinical; Data; Data Collection; Devices; Evaluation; Event; Feedback; Feeling; Focus Groups; Grant; Health Sciences; Hematopoietic stem cells; Home environment; Hour; Individual; Internet; Lead; Measurement; Measures; Medical Research; Methodology; Methods; Monitor; Nurses; Patients; Performance; Personal Satisfaction; Physicians; Property; Psychometrics; Quality of life; Questionnaires; Reference Standards; Relative (related person); Research; Stem cell transplant; Suggestion; Time; Transplant Recipients; Variant; Visual; Work; analog; base; behavioral health; behavioral/social science; experience; expiration; improved; longitudinal database; novel; novel strategies; programs; public health relevance; response; sound; theories; web site

DESCRIPTION (provided by applicant): The broad objective of this application is to improve measurement of quality of life in the behavioral and health sciences by developing a novel assessment method and demonstrating its feasibility in patients who have had hematopoietic stem cell transplants. The new approach asks the patient to use a highly intuitive interface [VIsual Time Analog (VITA)] to partition the day into mutually exclusive, clinically valid, states of quality of life. The partitions provided by the patients generate ordered categorical response states that have very desirable psychometric and statistical properties, and which will be suitable for individual clinical monitoring as well as trial endpoints. This R21 second resubmission responds to PA-06-351 (Exploratory Grants for Behavioral Research in Cancer Control [R21]), following the expiration of PA-06-343. Focus groups will be conducted to obtain patient evaluations of the ease of use and the meaningfulness of the VITA measurement device. In addition, we will obtain feedback from clinicians regarding the clinical meaningfulness of data obtained with the new device. A data collection study will be conducted with 60 patients who will use the VITA format to rate eight areas of well-being through a website program. Both brief daily and longer monthly assessments will occur over a three-month period from the patient's home. We hypothesize that the new research will lead to more valid and sensitive measurement of patient QOL. We believe that the proposed assessment method will be more intuitively acceptable to patients. Clinicians will value the improved portrayal of how individuals differ, how they change over time, and the increased ability to predict important clinical events from these more sensitive QOL measures. PUBLIC HEALTH RELEVANCE: Quality of life (QOL) changes by the week, the day, and the hour; how these moments affect us becomes our QOL. In medical research, we use standardized questionnaires that usually try to summarize these changing states and feelings over a long period. This project offers a new method for capturing this important variation by asking patients to indicate the proportion of time during a day (or other period) they experience different levels of well-being.

描述（由申请人提供）：本申请的主要目的是通过开发一种新的评估方法并证明其在接受造血干细胞移植患者中的可行性，改善行为和健康科学中的生活质量测量。新方法要求患者使用高度直观的界面[可视化时间模拟（VITA）]将一天划分为相互排斥的，临床有效的生活质量状态。由患者提供的分区生成具有非常理想的心理测量和统计特性的有序分类响应状态，并且其将适合于个体临床监测以及试验终点。在PA-06-343到期后，R21第二次重新提交响应PA-06-351（癌症控制行为研究探索性赠款[R21]）。将进行焦点小组调查，以获得患者对VITA测量设备的易用性和意义的评价。此外，我们还将从临床医生处获得关于使用新器械获得的数据的临床意义的反馈。将对60名患者进行数据收集研究，这些患者将使用VITA格式通过网站程序对八个方面的福祉进行评级。在三个月的时间内，从患者家中进行每日简短评估和每月较长时间的评估。我们假设，新的研究将导致更有效和更敏感的测量患者的生活质量。我们相信，建议的评估方法将更直观地为患者所接受。临床医生将重视对个体差异的改善描述，他们如何随着时间的推移而变化，以及从这些更敏感的QOL指标预测重要临床事件的能力提高。公共卫生相关性：生活质量（QOL）随周、日和小时而变化;这些时刻如何影响我们成为我们的QOL。在医学研究中，我们使用标准化的问卷，通常试图总结这些长期变化的状态和感受。该项目提供了一种新的方法来捕捉这种重要的变化，要求患者指出他们在一天（或其他时间段）中体验不同水平的幸福感的时间比例。