DEVELOPMENT OF CORTICAL ORIENTATION COLUMNS

皮质定向柱的开发

• 批准号: 2535990
• 负责人: NAOUM P ISSA
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2535990
• 关键词: axon; developmental neurobiology; ferrets; lateral geniculate body; neural information processing; neural inhibition; neural transmission; neuroanatomy; orientation; retina; retinal bipolar neuron; single cell analysis; synapses; visual cortex

(1) Summary: the goal of this project is to define the mechanisms by which input from the retina and LGN directs the postnatal development of orientation selectivity in the ferret. This will be accomplished by (1) blocking retinal output with tetrodotoxin during development and (2) preventing axons from the LGN from reaching the cortex by destroying the cortical subplate. Following recovery from these manipulations,their effetcts will be assessed by optical and single unit recordings in the adult accompanied by an assessment of alterations in the cortical anatomy. The goal will be to describe disruptions in the normal corresponding physiological changes in neural response properties.

(1)摘要：本项目的目标是定义 通过视网膜和LGN的输入， 在雪貂中发展方向选择性。 这将是 通过（1）用河豚毒素阻断视网膜输出来实现 在发育过程中，（2）防止LGN的轴突 通过破坏皮质底板到达皮质 以下 从这些操作中恢复，将通过以下方法评估其效果： 光学和单一单位记录在成人伴随着一个 评估皮质解剖结构的变化。 我们的目标是 来描述正常的相应生理功能的中断， 神经反应特性的变化。