ACTIVATION OF SOXR--A FES CONTAINING GENE REGULATOR

生理性和非生理性产生的活性氧 中间体损害细胞元素，如DNA、蛋白质和脂类，并可能 对癌症、衰老等退行性疾病负责 进程。这项提议的目标是了解细胞如何防止 活性氧的潜在危害。控制对基因反应的基因 活性氧(氧化应激)是最近被分离出来的。一 系统中的超氧化物反应基因(soxRs基因)，已经引出了特殊的 请注意，SOXRS不仅可以被超氧化物激活，还可以被 一氧化氮。SoxRS基因编码两种蛋白质，SoxR和SoxS。SOXR是 被认为是氧化还原感受器，并控制Soxs基因的表达 其产物SOXS然后刺激一组基因的表达 对防御功能进行编码。最近的证据表明，SoxR包含一个 SoxR到SoxR中的2Fe2S所需的[2Fe2S]群集，以及 探索其组装和拆卸流程。

Physiologically and non-physiologically generated reactive oxygen intermediates damage cell elements such as DNA, protein and lipids, and may be responsible for degenerative diseases, such as cancer, and the aging process. The goal of this proposal is to understand how cells prevent the potential damage by reactive oxygen. Genes that control the responses to reactive oxygen (oxidative stress) have been isolated recently. One system, the superoxide response genes (soxRS gene), has drawn a special attention since soxRS can be activated not only by superoxide, but also by nitric oxide. The soxRS genes encode two proteins, SoxR and SoxS. SoxR is considered as a redox sensor, and controls the expression of the soxS gene whose product SoxS then stimulates expression of a group of genes that encode defense functions. Recent evidence indicates that SoxR contains a [2Fe2S] cluster that is required for SoxR to 2Fe2S] cluster in SoxR, and exploring its assembly and disassembly processes.