ACTIVATION OF SOXR--A FES CONTAINING GENE REGULATOR

生理和非生理产生的活性氧 中间体破坏细胞成分，如DNA、蛋白质和脂质， 负责退化性疾病，如癌症，和老化 过程 这项提案的目标是了解细胞如何阻止 活性氧的潜在危害。 基因控制着 活性氧（氧化应激）最近被分离出来。 一 系统，超氧化物反应基因（soxRS基因），已经绘制了一个特殊的 注意，因为soxRS不仅可以被超氧化物激活，而且可以被 一氧化氮 soxRS基因编码两种蛋白，SoxR和SoxS。 SoxR是 被认为是氧化还原传感器，并控制soxS基因的表达 其产物SoxS刺激一组基因的表达， 编码防御功能。 最近的证据表明，SoxR含有一种 SoxR中的SoxR到2Fe2S]簇所需的[2Fe2S]簇，和 探索它的组装和拆卸过程。

Physiologically and non-physiologically generated reactive oxygen intermediates damage cell elements such as DNA, protein and lipids, and may be responsible for degenerative diseases, such as cancer, and the aging process. The goal of this proposal is to understand how cells prevent the potential damage by reactive oxygen. Genes that control the responses to reactive oxygen (oxidative stress) have been isolated recently. One system, the superoxide response genes (soxRS gene), has drawn a special attention since soxRS can be activated not only by superoxide, but also by nitric oxide. The soxRS genes encode two proteins, SoxR and SoxS. SoxR is considered as a redox sensor, and controls the expression of the soxS gene whose product SoxS then stimulates expression of a group of genes that encode defense functions. Recent evidence indicates that SoxR contains a [2Fe2S] cluster that is required for SoxR to 2Fe2S] cluster in SoxR, and exploring its assembly and disassembly processes.