NEUROPHYSIOLOGICAL EVALUATION OF A MOTOR CONTROL MODEL

运动控制模型的神经生理学评估

• 批准号: 2421279
• 负责人: PAUL E CISEK
• 金额: $ 2.03万
• 依托单位: UNIVERSITY OF MONTREAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2421279
• 关键词: Macaca mulatta; biological models; evaluation /testing; neuroanatomy; neurophysiology; psychomotor function; sensorimotor system

The purpose of the proposed project is to evaluate a model of cortical motor control through a series of neurophysiological experiments. The model tested has been developed based on a diverse set of physiological, anatomical, and psychophysical data, with particular focus on data about cell responses in cortical areas 4 and 5 during voluntary and passive movements. Because the model proposes specific functional roles to different neural regions, it makes specific predictions regarding cell responses in these regions during novel experimental paradigms. The particular hypotheses to be tested are the proposals that tonic activities in area 4 correspond to a descending command that combines both position and force information, and that tonic activities in anterior area 5 correspond to a representation of current limb position. These hypotheses make predictions regarding the difference in cell responses between areas 4 and 5 during tasks which dissociate force-and-position information from pure position information. Two experimental paradigms are proposed to test this, one involving a comparison between isometric movements and movements with a pendulum, the other involving movements in the presence of obstacles. Aside from its relevance to the model being tested, the data obtained is expected to contribute to the understanding of cortical function during voluntary movement.

该项目的目的是评估一个模型的皮质 通过一系列的神经生理学实验来研究运动控制。 测试的模型是根据一组不同的 生理、解剖和心理物理数据，特别是 重点关注在大脑皮层4区和5区的细胞反应的数据， 主动和被动运动。 因为这个模型提出 不同的神经区域，它使特定的功能作用， 在新的治疗过程中，这些区域的细胞反应预测 实验范例 待检验的特定假设是 第4区的主音活动对应于下行活动， 结合位置和力信息的命令， 前区5中的紧张性活动对应于 当前肢体位置。 这些假设预测了 在任务期间，区域4和区域5之间的细胞反应的差异 将力和位置信息从纯位置中分离出来 信息. 提出了两个实验范例来验证这一点， 一个涉及等长运动和 一种是用钟摆运动，另一种是用钟摆运动。 障碍的存在。 除了它与模型的相关性之外， 经过测试，获得的数据有望有助于理解 大脑皮层功能的变化