Marine sponge–microbe interactions and the origin of animal innate immunity

海绵与微生物的相互作用和动物先天免疫的起源

• 批准号: DP190102521
• 负责人: Prof Sandie Degnan
• 金额: $ 39.57万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102521
• 关键词: Marine; sponge; microbe; interactions; origin

This project aims to address how the animal innate immune system evolved to discriminate between potential pathogens versus beneficial symbionts by studying a marine sponge holobiont. Using advanced genomic and cellular approaches, the project will uncover deeply conserved regulatory pathways used by the cells of sponges, humans and other animals, and thereby identify cardinal rules governing animal innate immunity and its evolutionary origin. The project will provide an understanding of how beneficial microbial symbionts are recruited and maintained by animals, and are instrumental to the health of our environment and all its inhabitants.

该项目旨在通过研究海绵holobiont来解决动物先天免疫系统如何进化以区分潜在的病原体和有益的共生体。利用先进的基因组和细胞方法，该项目将揭示海绵，人类和其他动物细胞使用的高度保守的调控途径，从而确定控制动物先天免疫及其进化起源的主要规则。该项目将提供有益的微生物共生体是如何被动物招募和维持的理解，并有助于我们的环境及其所有居民的健康。