Cellular mechanics in unusual systems

不寻常系统中的细胞力学

• 批准号: DP190102230
• 负责人: Prof Alan Rowan
• 金额: $ 40.7万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102230
• 关键词: Cellular; mechanics; unusual; systems

This project aims to provide a fundamental understanding of how biomechanics influences stem cells under normal and microgravity conditions. This will be achieved by developing and validating simulated microgravity conditions on earth and establishing a valid system that mimics the extracellular matrix of living tissue in low gravity. The materials and technology generated will allow detailed insight into how force influences focal adhesion between cells and how this force is transferred from cell-to-cell in tissue. The findings from this project are expected to have significant benefit in controlling cell fate in space and on earth.

该项目旨在提供对生物力学如何在正常和微重力条件下影响干细胞的基本理解。这将通过在地球上开发和验证模拟微重力条件来实现，并建立一个模拟低重力下活组织细胞外基质的有效系统。所产生的材料和技术将允许详细了解力如何影响细胞之间的黏附，以及这种力如何在组织中从细胞转移到细胞。这个项目的发现有望对控制太空和地球上的细胞命运有重大的好处。