Cellular mechanics in unusual systems

该项目旨在提供生物力学如何影响干细胞在正常和微重力条件下的基本理解。这将通过开发和验证地球上的模拟微重力条件并建立一个有效的系统来实现，该系统模拟低重力下活组织的细胞外基质。所产生的材料和技术将允许详细了解力如何影响细胞之间的粘着斑，以及这种力如何在组织中从细胞转移到细胞。该项目的发现预计将对控制太空和地球上的细胞命运产生重大益处。

This project aims to provide a fundamental understanding of how biomechanics influences stem cells under normal and microgravity conditions. This will be achieved by developing and validating simulated microgravity conditions on earth and establishing a valid system that mimics the extracellular matrix of living tissue in low gravity. The materials and technology generated will allow detailed insight into how force influences focal adhesion between cells and how this force is transferred from cell-to-cell in tissue. The findings from this project are expected to have significant benefit in controlling cell fate in space and on earth.