Outside-In: Strain stiffening as a key to cell control

由外而内：应变硬化是细胞控制的关键

• 批准号: FL160100139
• 负责人: Prof Alan Rowan
• 金额: $ 202.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-06-30 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL160100139
• 关键词: Outside; Strain; stiffening; key; cell

Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processes inside the cell, including proliferation, differentiation and migration. Exactly how the physical and chemical properties of ECMs on the outside of the cell modify the behaviour of a cell on the inside remains unclear. Outcomes would include a blueprint for synthetic ECMs, pushing the boundaries of materials development in the biological and life sciences.

从外到内：应变硬化是细胞控制的关键。该研究项目旨在揭示细胞外基质高度复杂的力学行为，并开发一类全新的复杂和响应性强的细胞外基质(ECM)材料。在任何多细胞生物体中，ECM为细胞提供必要的机械(如应变硬化)和生化支持。细胞外基质对细胞内的生物过程也是至关重要的，包括增殖、分化和迁移。目前尚不清楚细胞外ECM的物理和化学性质如何改变细胞内部的行为。成果将包括合成ECM的蓝图，推动生物和生命科学中材料开发的界限。