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METABOTROPIC RECEPTOR LIGANDS

METABOTROPIC RECEPTOR LIGANDS
代谢受体配体
批准号:
2431314
负责人:
RODNEY L JOHNSON
金额:
$21.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-07-22 至 1999-05-31

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中文摘要
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英文摘要
DESCRIPTION: The objective of this research proposal is the development of selective and potent agonists and antagonists for various subtypes of metabotropic glutamate receptors. To this end, the following potential ligands will be synthesized: (1) Conformationally constrained analogs of L-AP4 in order to develop selective agonists; (2) analogs of methyl- L-AP4 to explore the basis behind its ability to serve as antagonist; (3) Analogs of quisqualic acid in which the oxadiazolidinedione ring is replaced with different other heterocyclic ring systems to generate selective agonists or antagonists of the mGluR1 and mGluR5 receptors; and (4) Conformationally constrained analogs of quisqualic acid in various conformations. These compounds will be evaluated for their ability to serve as agonists and antagonists at specific cloned and expressed metabotropic receptors. This research is intended to result in the discovery and development of agonists and antagonists for the various subtypes of metabotropic receptors that have been discovered.
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400 MHz NMR Spectrometer
  • 批准号:
    7387889
  • 项目类别:
  • 资助金额:
    $34.55万
  • 财政年份:
    2008
  • 负责人:
    RODNEY L JOHNSON
  • 依托单位:
PRO LEU GLY NH2 & DOPAMINE RECEPTOR MODULATION
  • 批准号:
    6665835
  • 项目类别:
  • 资助金额:
    $15.75万
  • 财政年份:
    2002
  • 负责人:
    RODNEY L JOHNSON
  • 依托单位:
PRO LEU GLY NH2 & DOPAMINE RECEPTOR MODULATION
  • 批准号:
    6486715
  • 项目类别:
  • 资助金额:
    $15.75万
  • 财政年份:
    2001
  • 负责人:
    RODNEY L JOHNSON
  • 依托单位:
PRO LEU GLY NH2 & DOPAMINE RECEPTOR MODULATION
  • 批准号:
    6336785
  • 项目类别:
  • 资助金额:
    $0.13万
  • 财政年份:
    2000
  • 负责人:
    RODNEY L JOHNSON
  • 依托单位:
海外基金