400 MHz NMR Spectrometer

描述(由申请者提供)：这项设备赠款正在申请资金，以400 MHz双道核磁共振光谱仪取代已有18年历史的核磁共振仪器，对由NIH资助的一组非常高效的药物化学研究人员合成的小分子进行一维和二维实验。这些小分子被用作配体和探针来研究各种生物系统。该仪器将取代1989年购买的老化的300 MHz瓦里安水星核磁共振。该仪器是大楼里唯一的核磁共振仪器，支持80多名研究人员的研究努力，这些研究人员不仅来自药物化学系，还来自明尼苏达大学学术健康中心的其他单位。该仪器将在行政上附属于学术健康中心内的核磁共振设施，这一核心设施将为核磁共振提供技术支持，费用将由药物化学系支付。这项申请的参与者包括由NIH资助数十年的知名研究人员(Hecht、Johnson、Portoghese、Siegel和Wagner)和在NIH支持下刚刚开始学术生涯的年轻教员(Aldrich、Fecik、Sturla、Tretyakova和Xing)。这些研究人员参与了美国国立卫生研究院资助的研究，这些研究要么涉及潜在药物靶标的小分子的设计和合成，要么涉及利用小分子配体研究与各种疾病相关的特定生物过程。他们的研究涉及许多不同的疾病领域，包括帕金森氏症、精神分裂症、疼痛、肺纤维化、抗癌治疗、癌症发生和结核病。

DESCRIPTION (provided by applicant): This equipment grant is requesting funds to replace an 18-year old NMR instrument with a 400 MHz 2 channel nuclear resonance spectrometer to perform 1D and 2D experiments on small molecules being synthesized by a group of very productive NIH-funded medicinal chemistry researchers. The small molecules are used as ligands and probes to investigate a variety of biological systems. The instrument would replace an aging 300 MHz Varian Mercury NMR that was purchased in 1989. The instrument is the only NMR in the building and supports the research endeavors of 80+ researchers from not only the Department of Medicinal Chemistry, but also from other units within the Academic Health Center at the University of Minnesota. The instrument would be administratively affiliated with the Nuclear Magnetic Resonance Facility within the Academic Health Center and this core facility would provide the technical support for the NMR, which will be paid for by the Department of Medicinal Chemistry. The participants in this application include well-established investigators who have been funded by NIH for decades (Hecht, Johnson, Portoghese, Siegel, and Wagner) and young faculty who are just beginning their academic careers with support by NIH (Aldrich, Fecik, Sturla, Tretyakova, and Xing). These investigators are involved in NIH funded research that deals either with the design and synthesis of small molecules for potential drug targets or the utilization of small molecule ligands to study particular biological processes associated with various diseases. Their research addresses a number of different disease areas including Parkinson's disease, schizophrenia, pain, pulmonary fibrosis, anticancer therapy, carcinogenesis, and tuberculosis.