400 MHz NMR Spectrometer

描述（由申请人提供）：本设备拨款申请资金，用于用400 MHz 2通道核磁共振光谱仪取代已有18年历史的核磁共振仪器，对一组非常高效的nih资助的药物化学研究人员合成的小分子进行1D和2D实验。这些小分子被用作配体和探针来研究各种生物系统。该仪器将取代1989年购买的老化的300 MHz瓦里安汞核磁共振。该仪器是大楼中唯一的核磁共振仪器，不仅支持药物化学系的80多名研究人员的研究工作，还支持明尼苏达大学学术健康中心其他单位的研究工作。该仪器将在行政上隶属于学术健康中心内的核磁共振设施，该核心设施将为核磁共振提供技术支持，该技术支持将由药物化学系支付。该申请的参与者包括由NIH资助了数十年的知名研究人员（Hecht, Johnson, Portoghese， Siegel和Wagner）和在NIH支持下刚刚开始学术生涯的年轻教师（Aldrich, Fecik, Sturla， Tretyakova和Xing）。这些研究者参与了美国国立卫生研究院资助的研究，这些研究涉及设计和合成潜在药物靶点的小分子，或利用小分子配体研究与各种疾病相关的特定生物过程。他们的研究涉及许多不同的疾病领域，包括帕金森病、精神分裂症、疼痛、肺纤维化、抗癌治疗、致癌和结核病。

DESCRIPTION (provided by applicant): This equipment grant is requesting funds to replace an 18-year old NMR instrument with a 400 MHz 2 channel nuclear resonance spectrometer to perform 1D and 2D experiments on small molecules being synthesized by a group of very productive NIH-funded medicinal chemistry researchers. The small molecules are used as ligands and probes to investigate a variety of biological systems. The instrument would replace an aging 300 MHz Varian Mercury NMR that was purchased in 1989. The instrument is the only NMR in the building and supports the research endeavors of 80+ researchers from not only the Department of Medicinal Chemistry, but also from other units within the Academic Health Center at the University of Minnesota. The instrument would be administratively affiliated with the Nuclear Magnetic Resonance Facility within the Academic Health Center and this core facility would provide the technical support for the NMR, which will be paid for by the Department of Medicinal Chemistry. The participants in this application include well-established investigators who have been funded by NIH for decades (Hecht, Johnson, Portoghese, Siegel, and Wagner) and young faculty who are just beginning their academic careers with support by NIH (Aldrich, Fecik, Sturla, Tretyakova, and Xing). These investigators are involved in NIH funded research that deals either with the design and synthesis of small molecules for potential drug targets or the utilization of small molecule ligands to study particular biological processes associated with various diseases. Their research addresses a number of different disease areas including Parkinson's disease, schizophrenia, pain, pulmonary fibrosis, anticancer therapy, carcinogenesis, and tuberculosis.