课题基金 / 基金详情

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS
用微胶囊药物治疗结核病
批准号：
2457826
负责人：
William W Barrow
金额：
$46.12万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-08-01 至 1999-07-31
来源：
https://reporter.nih.gov/project-details/2457826
关键词：
antitubercular agents drug design /synthesis /production drug screening /evaluation ethambutol isoniazid laboratory mouse lymphocyte proliferation microcapsule phagocytosis rifamycins streptomycin tissue /cell culture

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英文摘要
DESCRIPTION: (Adapted from Applicant's Abstract). TB is an important infection worldwide and its incidence is increasing in the U. S. In view of this, much interest has been directed to the development of novel drugs or delivery systems that are effective against the infection to improve patient survival. This application deals with the development of microencapsulated anti-TB drugs with the hope of accomplishing the aforementioned goal. Once developed, these drugs will be tested in vitro, using a murine macrophage cell line and a human monocytic cell line. Afterwards, the drugs will be tested in mice infected with MTB.
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