Antifolates Against Mycobacterial Infections in AIDS

抗叶酸剂对抗艾滋病分枝杆菌感染

• 批准号: 6631969
• 负责人: William W Barrow
• 金额: $ 42.54万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6631969
• 关键词: AIDS; Actinomycetales infection; Mycobacterium avium; Mycobacterium tuberculosis; Vero cells; antitubercular agents; bacterial proteins; chemical synthesis; dihydrofolate reductase; drug screening /evaluation; enzyme activity; folate antagonist; laboratory mouse; microorganism disease chemotherapy; molecular cloning; nonhuman therapy evaluation; oxidoreductase inhibitor; recombinant proteins; respiratory disorder chemotherapy

项目成果

New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.

新型鸟分枝杆菌抗叶酸剂与二氢蝶酸合酶抑制剂联合使用时显示出协同效应。

• DOI: 10.1128/aac.49.11.4801-4803.2005
• 发表时间: 2005
• 期刊: Antimicrobial agents and chemotherapy.
• 作者: Suling,WJ;Seitz,LE;Reynolds,RC;Barrow,WW
• 通讯作者: Barrow,WW

New antifolate inhibitors for Mycobacterium avium.

• DOI: 10.2174/157340606778250225
• 发表时间: 2006-09-01
• 期刊: Medicinal chemistry (Shariqah (United Arab Emirates))
• 作者: Barrow, E W;Suling, W J;Barrow, W W
• 通讯作者: Barrow, W W