课题基金 / 基金详情

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS
用微胶囊药物治疗结核病
批准号：
2672524
负责人：
William W Barrow
金额：
$38.79万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-08-01 至 2000-07-31
来源：
https://reporter.nih.gov/project-details/2672524
关键词：
antitubercular agents drug design /synthesis /production drug screening /evaluation ethambutol isoniazid laboratory mouse lymphocyte proliferation microcapsule phagocytosis rifamycins streptomycin tissue /cell culture

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中文摘要
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英文摘要
DESCRIPTION: (Adapted from Applicant's Abstract). TB is an important infection worldwide and its incidence is increasing in the U. S. In view of this, much interest has been directed to the development of novel drugs or delivery systems that are effective against the infection to improve patient survival. This application deals with the development of microencapsulated anti-TB drugs with the hope of accomplishing the aforementioned goal. Once developed, these drugs will be tested in vitro, using a murine macrophage cell line and a human monocytic cell line. Afterwards, the drugs will be tested in mice infected with MTB.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
Microsphere technology for chemotherapy of mycobacterial infections.
用于分枝杆菌感染化疗的微球技术。
DOI： 10.2174/1381612043383197
发表时间： 2004
期刊： Current pharmaceutical design
影响因子： 3.1
作者： [Barrow,WilliamW]
通讯作者： Barrow,WilliamW
Efficacy of rifabutin-loaded microspheres for treatment of Mycobacterium avium-infected macrophages and mice.
负载利福布丁的微球治疗鸟分枝杆菌感染的巨噬细胞和小鼠的功效。
DOI： 10.1080/10717540600739815
发表时间： 2007
期刊： Drug delivery
影响因子： 6
作者： [Barrow,EstherLW, Barrow,WilliamW, Quenelle,DebraC, Westbrook,Louise, Winchester,GaryA, Staas,JayK]
通讯作者： Staas,JayK
Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice.
微囊利福平对结核分枝杆菌感染小鼠的功效。
DOI： 10.1128/aac.43.5.1144
发表时间： 1999
期刊： Antimicrobial agents and chemotherapy
影响因子： 4.9
作者： [Quenelle,DC, Staas,JK, Winchester,GA, Barrow,EL, Barrow,WW]
通讯作者： Barrow,WW
Treatment of tuberculosis using a combination of sustained-release rifampin-loaded microspheres and oral dosing with isoniazid.
使用缓释利福平微球和口服异烟肼相结合治疗结核病。
DOI： 10.1128/aac.45.6.1637-1644.2001
发表时间： 2001
期刊： Antimicrobial agents and chemotherapy
影响因子： 4.9
作者： [Quenelle,DC, Winchester,GA, Staas,JK, Barrow,EL, Barrow,WW]
通讯作者： Barrow,WW
Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracis
Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracis
Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracis
Broad-spectrum Antifolates for Treatment of Drug Resistant Bacillus anthracis