SECOND MESSENGER SIGNALS IN DEVELOPING OLFACTORY NEURONS

嗅觉神经元发育中的第二信使信号

• 批准号: 2667286
• 负责人: TRESE LEINDERS-ZUFALL
• 金额: $ 10.49万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2667286
• 关键词: Urodela; biological signal transduction; calcium ion; developmental neurobiology; electrophysiology; membrane channels; nervous system regeneration; neurophysiology; nucleotides; olfactions; olfactory nerve; receptor expression; second messengers; voltage gated channel

DESCRIPTION: (Adapted from the Applicant=s Abstract) Cyclic nucleotide gated (CNG) ion channels and second messenger pathways that play an important role i odor transduction are also used during development to regulate the connectivit of olfactory receptor neurons. This proposal is to study the presence of these second messenger pathways in developing olfactory receptor neurons to gain insight into the mechanisms underlying the development of olfactory function, and possibly of neurons in general. The electrical properties of regenerating olfactory receptor neurons, in particular the time course of expression of voltage-activated channels, will be studied to provide a time line for the system. Second, preliminary evidence that CNG channels appear early in development will be expanded to delineate the physiological pathways that regulate these channels, with particular emphasis on possible regulation by th gaseous second messengers NO and CO. Finally, calcium imaging will be used to determine if activation of CNG channels allows calcium entry that is critical to implement developmental changes in these neurons. Knowledge about the precise mechanisms involved in the development of the olfactory system may yield new clinical insight into disorders associated with neuron replacement and functional repair following nerve injury.

描述：(改编自申请人=S摘要)环核苷酸 门控(CNG)离子通道和第二信使通路 重要作用I气味转导在发育过程中也被用于 调节嗅觉感受器神经元的连接。这项建议是为了 研究发育过程中这些第二信使途径的存在 嗅觉感受器神经元深入了解潜在的机制 嗅觉功能的发展，可能还有一般神经元的发展。 再生的嗅觉感受器神经元的电特性 特别是电压激活通道的表达的时间进程，将 研究为该系统提供一条时间线。第二，初选 CNG渠道出现在发展早期的证据将扩大到 描绘调节这些通道的生理途径， 特别强调TH气体第二信使的可能调节 不是和CO。最后，将使用钙成像来确定是否激活 CNG通道允许钙内流，这对实施至关重要 这些神经元的发育变化。精确度知识 涉及嗅觉系统发展的机制可能会产生新的 临床洞察与神经元替代相关的疾病和 神经损伤后的功能修复。