SECOND MESSENGER SIGNALS IN DEVELOPING OLFACTORY NEURONS

嗅觉神经元发育中的第二信使信号

• 批准号: 6516185
• 负责人: TRESE LEINDERS-ZUFALL
• 金额: $ 11万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2004-02-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516185
• 关键词: Urodela; biological signal transduction; calcium ion; developmental neurobiology; electrophysiology; membrane channels; nervous system regeneration; neurophysiology; nucleotides; odors; olfactions; olfactory nerve; receptor expression; second messengers; voltage gated channel

DESCRIPTION: (Adapted from the Applicant=s Abstract) Cyclic nucleotide gated (CNG) ion channels and second messenger pathways that play an important role i odor transduction are also used during development to regulate the connectivit of olfactory receptor neurons. This proposal is to study the presence of these second messenger pathways in developing olfactory receptor neurons to gain insight into the mechanisms underlying the development of olfactory function, and possibly of neurons in general. The electrical properties of regenerating olfactory receptor neurons, in particular the time course of expression of voltage-activated channels, will be studied to provide a time line for the system. Second, preliminary evidence that CNG channels appear early in development will be expanded to delineate the physiological pathways that regulate these channels, with particular emphasis on possible regulation by th gaseous second messengers NO and CO. Finally, calcium imaging will be used to determine if activation of CNG channels allows calcium entry that is critical to implement developmental changes in these neurons. Knowledge about the precise mechanisms involved in the development of the olfactory system may yield new clinical insight into disorders associated with neuron replacement and functional repair following nerve injury.

描述：（改编自申请人的摘要）环核苷酸 门控（CNG）离子通道和第二信使途径，发挥作用， 在发育过程中也使用重要作用I气味传导， 调节嗅觉受体神经元的连接。 这项建议是为了 研究这些第二信使通路在发育中的存在， 嗅觉受体神经元，以深入了解其机制 嗅觉功能的发展，可能还有神经元的发展。 再生嗅觉受体神经元的电特性， 特别是电压激活通道表达的时程， 为系统提供一个时间表。 第二，初步 CNG通道出现在发展早期的证据将扩大到 描绘调节这些通道的生理途径， 特别强调气体第二信使的可能调节 NO和CO。最后，钙成像将用于确定是否激活 CNG通道允许钙进入， 这些神经元的发育变化。 关于精准的知识 参与嗅觉系统发育的机制可能产生新的 对神经元替代相关疾病的临床见解， 神经损伤后的功能修复。