AMBIENT AIR POLLUTION AND CARDIOVASCULAR MORBIDITY

描述：(改编自申请人的摘要)：研究 与空气污染相关的发病率和死亡率在历史上 专注于呼吸道疾病。调查人员的初步研究 将空气监测数据与医疗保险管理数据一起使用 证明每天的一氧化碳(CO)水平和 空气中直径小于10微米的颗粒物(PM10)每天 因心血管疾病接受医疗保险的人的入院情况。 拟议的研究将扩展这些分析，以探索两者之间的联系 空气污染与心血管疾病的关系及其调查因素 这可能会影响这种联系。四个具体的假设将是 地址。首先，我们建议看看独立和互动的 这些污染物对更广泛的心血管疾病的影响 与初步研究中考虑的八个不同的城市 确定这些关系的一致性。第二，我们将审查 温湿度对心血管的调节作用 这些污染物的影响。第三，我们将考察 颗粒物与心血管关系中的颗粒物特征 使用来自费城的详细抽样数据。最后，我们会 研究由患有以下疾病的人组成的医疗保险受益人亚群体 慢性呼吸系统疾病住院史评价 心血管疾病与空气之间的关联程度 污染是由呼吸影响驱动的。鉴于这一事件的巨大影响 心血管疾病对公众健康的影响，空气污染 在这些疾病的恶化中扮演着重要的角色 后果。拟议中的研究试图扩展我们的知识 关于空气污染对健康的影响，在这个重要的新 方向。

DESCRIPTION: (Adapted from the Applicant's Abstract): The study of morbidity and mortality associated with air pollution historically has focused on respiratory disease. Preliminary studies by the investigators using air monitoring data together with Medicare administrative data demonstrate an association of daily levels of both carbon monoxide (CO) and airborne particulates less than 10 microns in diameter (PM10) with daily hospital admissions among Medicare recipients for cardiovascular disease. The proposed study will extend these analyses to explore the association between air pollution and cardiovascular disease and the investigate factors that may affect that association. Four specific hypotheses will be addressed. First, we propose to look at the independent and interactive effects of these pollutants on a broader range of cardiovascular conditions in eight different cities than considered in preliminary studies to determine the consistency of these relationships. Second, we will examine the modulating effect of temperature and humidity on the cardiovascular effects of these pollutants. Third, we will examine the influence of particle characteristics on the link between particulates and cardiovascular disease using detailed sampling data from Philadelphia. Finally, we will study a sub-population of Medicare beneficiaries comprised of persons with a history of hospital admissions for chronic respiratory disease to evaluate degree to which the association between cardiovascular disease and air pollution is driven by respiratory effects. Given the tremendous impact of cardiovascular disease on public health, the possibility that air pollution plays a significant role in the exacerbation of these conditions has major ramifications. The proposed research seeks to extend our knowledge concerning the health effects of air pollution in this important new direction.