CHLORIDE REGULATION OF PHOTORECEPTOR NEUROTRANSMISSION
光感受器神经传递的氯化物调节
基本信息
- 批准号:2711106
- 负责人:
- 金额:$ 9.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-06-01 至 2001-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Small reductions in extracellular chloride suppress light-evoked currents
in second-order retinal neurons. Thus, physiological regulation of
chloride in and around photoreceptors may act in concert with
photoreceptor membrane voltage to control transmitter release at this
critical first synapse in vision. Regulation of photoreceptor
neurotransmission by chloride could affect vision in many ways. For
example, changes in chloride levels during sustained illumination might
play a role in post-receptoral adaption; chloride fluxes during
illumination of the cone receptive field surround could adjust the
strength of surround antagonism; and activity-dependent changes in
chloride should alter the balance between ON and OFF light responses
(which could account for the enhanced sensitivity of ON retinal ganglion
cells to ischemia). To assess possible functions of chloride regulation,
it is essential to understand the mechanism(s) responsible for the
suppression of transmitter release from photoreceptors induced by
reductions in extracellular chloride.
Besides suppressing light-evoked currents in horizontal and bipolar
cells, reducing chloride suppresses the dihydropyridine-sensitive calcium
current in photoreceptors. Suppression of this current by dihydropyridine
antagonists reduces light responses in second-order retinal neurons.
Therefore, it is hypothesized that the suppression of light-evoked
currents in second order retinal neurons may arise as a consequence of
the suppression of photoreceptor calcium currents induced by reductions
in chloride. The two major aims of this proposal are to test this
hypothesis further and to analyze the mechanism(s) by which chloride may
influence calcium channel function. Whole cell and single channel patch
clamp recordings will be used to study the chloride sensitivity of
photoreceptor calcium currents, as well as currents evoked by light and
spontaneous quantal release in horizontal and bipolar cells of the
amphibian retina. These experiments should provide an understanding of
the photoreceptor mechanisms responsible for chloride regulation and
provide a sound basis for future studies into possible functions of this
newly identified regulatory mechanism.
细胞外氯离子的少量减少可抑制光诱发电流
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('WALLACE B THORESON', 18)}}的其他基金
CHLORIDE REGULATION OF PHOTORECEPTOR NEUROTRANSMISSION
光感受器神经传递的氯化物调节
- 批准号:
2888443 - 财政年份:1996
- 资助金额:
$ 9.86万 - 项目类别:
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