ANTIATHEROGENIC EFFECTS OF MODERATE ALCOHOL USE

适量饮酒的抗动脉粥样硬化作用

• 批准号: 2516856
• 负责人: MARY J MALLOY
• 金额: $ 20.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2516856
• 关键词: alcoholic beverage consumption; antiatherogenic agent; atherosclerosis; cardiovascular disorder epidemiology; cardiovascular pharmacology; cholesterol; clinical research; estrogens; high density lipoproteins; human subject; immunoaffinity chromatography; lipid transport; low density lipoprotein

APPLICANT'S ABSTRACT: Coronary atherosclerosis is the leading cause of death in the United States in both women and men. Several epidemiologic studies have found decreased mortality from coronary disease among people who use alcohol moderately. It is known that many individuals who consume alcohol even in small amounts have increased levels of total plasma high density lipoproteins (HDL). This effect may mediate at least a portion of the effect of alcohol on cardiovascular mortality because it is well known that higher levels of HDL are associated with lower risk. This project is directed at elucidation of the effects of moderate alcohol consumption on HDL and its antiatherogenic functions at the molecular level. Previous attempts to understand these effects have been impeded by the fact that the method heretofore employed to separate HDL species, i.e. ultracentrifugation, has been found to disrupt their architecture such that they cannot be effectively studied. This project will exploit major advances in immunosorption techniques that permit measurement of the effects of alcohol on the native molecular species of HDL, avoiding ultracentrifugation, and will assess the effects on two antiatherogenic functions of HDL, the inhibition of oxidation of low density lipoproteins, and the retrieval of cholesterol from cells. The results of these studies will be important in establishing public health policy with respect to the relative benefits and risks of moderate alcohol consumption.

申请人摘要：冠状动脉粥样硬化是导致以下疾病的主要原因 在美国，女性和男性均死亡。 几种流行病学 研究发现冠心病死亡率降低 适度饮酒的人。 据了解，不少消费人群 即使少量的酒精也会增加血浆总浓度 密度脂蛋白（HDL）。 这种效应可能会介导至少一部分 酒精对心血管死亡率的影响是众所周知的 高密度脂蛋白水平越高，风险越低。 这个项目是 旨在阐明适量饮酒对健康的影响 HDL 及其在分子水平上的抗动脉粥样硬化功能。 以前的 由于以下事实，理解这些影响的尝试受到了阻碍： 迄今为止用于分离 HDL 种类的方法，即 超速离心已被发现会破坏其结构，从而 它们无法得到有效的研究。 该项目将利用主要 免疫吸附技术的进步可以测量效果 酒精对 HDL 天然分子种类的影响，避免 超速离心，并将评估两种抗动脉粥样硬化的效果 HDL的功能，抑制低密度脂蛋白的氧化， 以及从细胞中回收胆固醇。 这些研究的结果 对于制定有关以下方面的公共卫生政策非常重要 适量饮酒的相对益处和风险。