ANTIATHEROGENIC EFFECTS OF MODERATE ALCOHOL USE

适量饮酒的抗动脉粥样硬化作用

• 批准号: 6168341
• 负责人: MARY J MALLOY
• 金额: $ 22.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168341
• 关键词: alcoholic beverage consumption; antiatherogenic agent; atherosclerosis; cardiovascular disorder epidemiology; cardiovascular pharmacology; cholesterol; clinical research; estrogens; high density lipoproteins; human subject; immunoaffinity chromatography; lipid transport; low density lipoprotein

APPLICANT'S ABSTRACT: Coronary atherosclerosis is the leading cause of death in the United States in both women and men. Several epidemiologic studies have found decreased mortality from coronary disease among people who use alcohol moderately. It is known that many individuals who consume alcohol even in small amounts have increased levels of total plasma high density lipoproteins (HDL). This effect may mediate at least a portion of the effect of alcohol on cardiovascular mortality because it is well known that higher levels of HDL are associated with lower risk. This project is directed at elucidation of the effects of moderate alcohol consumption on HDL and its antiatherogenic functions at the molecular level. Previous attempts to understand these effects have been impeded by the fact that the method heretofore employed to separate HDL species, i.e. ultracentrifugation, has been found to disrupt their architecture such that they cannot be effectively studied. This project will exploit major advances in immunosorption techniques that permit measurement of the effects of alcohol on the native molecular species of HDL, avoiding ultracentrifugation, and will assess the effects on two antiatherogenic functions of HDL, the inhibition of oxidation of low density lipoproteins, and the retrieval of cholesterol from cells. The results of these studies will be important in establishing public health policy with respect to the relative benefits and risks of moderate alcohol consumption.

摘要：冠状动脉粥样硬化是导致

项目成果

The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.

混合性高脂血症中的脂蛋白脂肪酶基因：保护性等位基因耗竭的证据。

• DOI: 10.1186/1476-511x-5-19
• 发表时间: 2006
• 期刊: Lipids in health and disease [electronic resource].
• 作者: Wung,Shu-Fen;Kulkarni,MedhaV;Pullinger,CliveR;Malloy,MaryJ;Kane,JohnP;Aouizerat,BradleyE
• 通讯作者: Aouizerat,BradleyE

Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype.

土耳其人的高密度脂蛋白水平较低，而土耳其人的肝脂肪酶水平较高。

• 发表时间: 2000
• 期刊: Journal of lipid research
• 影响因子: 6.5
• 作者: Mahley,RW;Pépin,J;Palaoğlu,KE;Malloy,MJ;Kane,JP;Bersot,TP
• 通讯作者: Bersot,TP