DETERMINANTS OF CORONARY DISEASE IN WOMEN

女性冠心病的决定因素

• 批准号: 3741112
• 负责人: MARY J MALLOY
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3741112
• 关键词: angiocardioultrasonography; angiography; biomarker; case history; coronary disorder; disease /disorder proneness /risk; female; high density lipoproteins; hormone metabolism; human subject; low density lipoprotein; sex hormones

The goal of this study is to identify new biochemical determinants of risk for coronary disease in women. Speciation of both high and low density lipoproteins and studies of sex hormones and their metabolites will be correlated with distribution and severity of coronary lesions. The latter will be characterized by quantitative coronary angiography and quantitative intracoronary ultrasound. Patients will be seen the GCRC outpatient unit for dietary/medical histories,etc and will be hospitalized on the GCRC for invasive studies and blood studies.

这项研究的目的是确定新的生化决定因素， 女性患冠心病的风险。 高和低物种形成 密度脂蛋白与性激素及其代谢产物的研究 将与冠状动脉病变的分布和严重程度相关。 后者将通过定量冠状动脉造影术表征， 定量冠状动脉内超声。 患者将接受GCRC检查 饮食/病史等门诊单位，并将 在GCRC住院进行侵入性研究和血液研究。