A new source of bivalent molecules from nature

自然界二价分子的新来源

• 批准号: DP190101177
• 负责人: Prof Mehdi Mobli
• 金额: $ 29.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2022-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101177
• 关键词: new; source; bivalent; molecules; nature

This project aims to describe a new class of naturally occurring multivalent molecules termed secreted cysteine-rich repeat proteins (SCREPs). Multivalency is a key feature of molecular interaction in biology, underlying the high specificity and potency found in many proteins. Focusing on bivalent peptides, the project will generate a database of bioactive SCREPs with similarity to known bioactive peptides, and develop new recombinant methods for their production. The project will use advanced nuclear magnetic resonance spectroscopy to characterise members of this new class, providing new insights into the design of bivalent and multivalent peptides and establishing a new source of molecules with applications in the rapidly growing biotechnology sector.

该项目旨在描述一类新的天然存在的多价分子，称为分泌型富含半胱氨酸重复蛋白（SCREPs）。多价性是生物学中分子相互作用的一个关键特征，是许多蛋白质中发现的高特异性和效力的基础。以二价肽为重点，该项目将生成与已知生物活性肽相似的生物活性SCREP数据库，并开发新的重组方法用于生产。该项目将使用先进的核磁共振光谱来识别这一新类别的成员，为二价和多价肽的设计提供新的见解，并建立一个新的分子来源，并在快速增长的生物技术领域中应用。