Autocyclases: A new class of self-cyclising proteins

自环化酶：一类新的自环化蛋白

• 批准号: DP220103028
• 负责人: Prof Mehdi Mobli
• 金额: $ 31.12万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103028
• 关键词: Autocyclases; new; class; self; cyclising

The biotechnology sector is emerging as an important economic strength in Australia. While the improved efficacy and selectivity of biomolecules has seen them emerge as alternatives to existing chemicals in health and agriculture, the stability of biomolecules remains a major limiting factor. A general strategy for improving protein stability is by joining the ends of the peptide chain in a cyclisation reaction. While a wide range of cyclic peptides and proteins are being developed in Australia and around the world, the cyclisation reaction presents a significant challenge. In this proposal we detail a novel method for protein cyclisation as a general, low-cost and green production method for making a diverse range of biomolecules.

生物技术部门正在成为澳大利亚重要的经济力量。虽然生物分子的功效和选择性得到改善，已成为卫生和农业领域现有化学品的替代品，但生物分子的稳定性仍然是一个主要限制因素。提高蛋白质稳定性的一般策略是在环化反应中加入肽链的末端。虽然在澳大利亚和世界各地正在开发各种环肽和蛋白质，但环化反应提出了一个重大挑战。在本提案中，我们详细介绍了一种新的蛋白质环化方法，作为一种通用的、低成本的、绿色的生产方法，用于制造各种生物分子。