Unravelling the structural complexity of ancient Australian arthropod venoms

揭开古代澳大利亚节肢动物毒液结构的复杂性

• 批准号: DP140101098
• 负责人: Prof Mehdi Mobli
• 金额: $ 10.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101098
• 关键词: Unravelling; structural; complexity; ancient; Australian

Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides.

动物毒液含有复杂的分子混合物，这些分子已经进化了数百万年，以靶向各种生物过程。它们精致的特异性和有效的活动使它们成为具有较少副作用或环保杀虫剂的治疗药物的有吸引力的发展来源。该项目的目的是首次探索所有已知类别的毒素的三维结构，这是两个古代澳大利亚节肢动物（蜘蛛和cent剂）的毒液中的三维结构。这将为这些毒液提供全面的概述，并为工程新的基于毒液的药物和杀虫剂提供机会。