Unravelling the structural complexity of ancient Australian arthropod venoms

揭开古代澳大利亚节肢动物毒液结构的复杂性

• 批准号: DP140101098
• 负责人: Prof Mehdi Mobli
• 金额: $ 10.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101098
• 关键词: Unravelling; structural; complexity; ancient; Australian

Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides.

动物毒液包含一种复杂的分子混合物，这些分子经过数百万年的进化，针对各种生物过程。它们精致的特异性和强大的活性使它们成为开发副作用较少的治疗药物或环境友好型杀虫剂的有吸引力的来源。该项目旨在首次探索澳大利亚两种古老节肢动物(蜘蛛和蜈蚣)毒液中所有已知毒素类别的三维结构。这将提供对这些毒液的全面概述，并为设计新的基于毒液的药物和杀虫剂提供机会。