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CONTROLLED STUDY OF ANABOLIC STEROID USE IN WOMEN

女性使用合成代谢类固醇的对照研究

基本信息

批准号：
2377427
负责人：
HARRISON G POPE
金额：
$ 10.73万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-03-01 至 1998-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2377427
关键词：
adipose tissue androgen analog blood chemistry body physical characteristic clinical research dosage drug abuse drug detection drug withdrawal female human subject interview mental health epidemiology physical fitness psychological tests toxicology urinalysis women's health

项目摘要

A growing literature suggests that anabolic-androgenic steroids, drugs which promote gains in muscle mass and loss of body fat, are widely abused by Americans. Many studies have shown that in men, steroids can lead to both medical and psychiatric morbidity. For example, a recent study from this laboratory, comparing 88 steroid-using men with 68 matched controls, found a markedly increased prevalence of major mood syndromes in association with both steroid use and steroid withdrawal. However, very few studies have examined the nature and effects of steroid use in women, despite evidence that more than 100,000 American women have abused these drugs. The study proposed in this application seeks to duplicate in women the investigators' previous design, used in the study of men described above. In the proposed study, 30 steroid-using women and 30 non-using women will be recruited from gymnasiums in two metropolitan areas, using a recruitment process designed to minimize selection bias. Subjects will be interviewed, using an instrument refined from the investigators' pilot study, and will submit urine to be tested for both steroids and other drugs. They will also receive a physical examination, including caliper determinations of body fat, and have blood drawn for standard chemistry and hematology measures. Users and non-users will be compared on basic demographic variables, medical history, physical and laboratory findings, and incidence of psychiatric symptoms and syndromes during and in the absence of steroid exposure. Although the proposed study is naturalistic, and relies on retrospective reports by subjects, this method represents the only design capable of assessing the nature and effects of steroid abuse in women, since it is not ethically reasonable to examine these effects in the laboratory.

越来越多的文献表明，合成代谢类固醇，药物促进肌肉质量的增加和身体脂肪的减少，被美国人虐待。许多研究表明，在男性中，类固醇可以导致医学和精神疾病。例如，最近该实验室的一项研究将88名使用类固醇的男性与68名使用类固醇的男性进行了比较，匹配的控制，发现一个显着增加流行的主要情绪与类固醇使用和类固醇戒断相关的综合征。然而，很少有研究检查类固醇的性质和作用，尽管有证据表明，超过10万名美国妇女滥用这些药物。本申请中提出的研究试图在女性中复制研究人员先前的设计，用于上述男性研究。在这项拟议的研究中，30名使用类固醇的妇女和30名不使用类固醇的妇女将从两个大都市地区的体育馆招募，使用招聘过程旨在尽量减少选择偏见。受试者将接受采访，使用从调查员的试点改进的工具研究，并将提交尿液进行测试类固醇和其他毒品他们还将接受身体检查，包括卡尺身体脂肪的测定，并有标准的化学抽血和血液学测量。使用者和非使用者将在基本上进行比较人口统计学变量、病史、体格检查和实验室检查结果，精神病症状和综合征的发病率没有类固醇暴露。尽管拟议的研究是自然主义的，并且依赖于回顾性的受试者的报告，这种方法代表了唯一的设计，评估妇女滥用类固醇的性质和影响，因为它是在实验室里检验这些影响在伦理上是不合理的。