INTERPLAY OF ALLERGIC RHINITIS AND NASAL HUMIDIFICATION

过敏性鼻炎和鼻腔加湿的相互作用

• 批准号: 2014598
• 负责人: ROBERT M NACLERIO
• 金额: $ 17.97万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2014598
• 关键词: antigens; controlled environment chamber; human subject; humidity; hypersensitivity; mucosa; nasopharynx; rhinitis; temperature

DESCRIPTION (Adapted from the applicant's abstract and specific aims): The nose functions to warm and humidify inhaled air. Few investigations have addressed this important function in healthy subjects, and none have systematically examined this function in patients with inflammatory nasal disease. The application proposes to investigate the interactions between the physiologic response of warming and humidifying inhaled air and allergic rhinitis, an inflammatory condition affecting over 40 million Americans. Inhaling cold (0 degrees C) and dry (<10% RH) air (CDA) in a laboratory provides a controlled model for evaluating the ability of the nose to warm and humidify air. Induction of an allergic reaction appears to augment the clinical response to the inhalation of CDA. It is also shown that continuous inhalation of warm (37 degrees C), moist (>90% RH) air prior to nasal antigen provocation reduces the immediate allergic response. It is hypothesized that these environmental conditions reduce the activity of the glands, nerves, blood vessels and other resident cells in the nose that are responsible for warming and humidifying inspired air. Thus, when stimulated by antigen, they react less vigorously. The nose provides a readily accessible human model to study the effects of allergic inflammation on the air-conditioning capacity of the nose and the influence of the environment on allergic inflammation. The application proposes to use nasal provocation techniques, a nasopharyngeal temperature and humidity sensor and an environmental chamber to test the hypotheses that: a) the induction of allergic inflammation reduces the ability of the nasal mucosa to warm and humidify CDA; b) the nasal response to CDA of individuals with perennial allergic rhinitis exceeds that of normal individuals; c) treatment of perennial rhinitic subjects with intranasal steroids reduces inflammation and improves the air-conditioning capacity of the nose; d) the symptomatic treatment of CDA induced rhinitis by anticholenergics reduces the ability of the nose to warm and humidify air; e) preconditioning the nasal mucosa in humid environments before antigenic provocation decreases the early, late, cellular and priming responses; and f) exposing the nose to warm, humid environments after antigenic stimulation reduces the subsequent inflammation, whereas exposing the mucosa to a cold, dry environment augments the inflammatory response. These experiments may expand our knowledge of the nasal response to two common environmental conditions and their interactions, potentially leading to new therapeutic strategies.

描述（根据申请人的摘要和具体目标改编）： 鼻子的功能是加热和加湿吸入的空气。很少调查 已经在健康受试者中解决了这一重要功能，但没有人 我系统地检查了炎症患者的这种功能， 鼻病 该申请建议调查 在变暖和吸入过量空气的生理反应之间 过敏性鼻炎，一种炎症性疾病， 百万美国人。 在实验室中吸入冷（0 ℃）和干燥（<10% RH）空气（CDA） 提供了一个控制模型，用于评估鼻子的能力， 温暖和潮湿的空气。 过敏反应的诱导似乎 增加对吸入CDA的临床反应。 也是 显示连续吸入温暖（37摄氏度），潮湿（>90%相对湿度） 鼻抗原激发前空气可降低即刻过敏反应 反应 据推测，这些环境条件降低了 腺体，神经，血管和其他居民的活动 鼻子里负责加温和降温的细胞 灵感的空气 因此，当被抗原刺激时，它们的反应较小， 大力地。 鼻子提供了一个易于使用的人体模型来研究其影响 过敏性炎症对鼻子的空调能力 以及环境对过敏性炎症的影响。 的 该申请提出使用鼻激发技术， 鼻咽温度和湿度传感器和环境 室测试的假设，即：a）过敏的诱导 炎症降低了鼻粘膜温热的能力， 加湿CDA; B）患有常年性鼻炎的个体对CDA的鼻反应 过敏性鼻炎超过正常人; c）治疗 用鼻内类固醇治疗常年性鼻炎患者可减轻炎症 并提高了鼻子的空调能力; d） 抗胆碱能药物对CDA诱发的鼻炎的对症治疗 降低鼻子加热和加湿空气的能力; e） 鼻粘膜在潮湿环境中预处理， 激发降低早期、晚期、细胞和启动反应; 和f）在抗原性后将鼻暴露于温暖、潮湿的环境中， 刺激减少了随后的炎症，而暴露 粘膜暴露于寒冷干燥的环境会增强炎症反应。 这些实验可能将我们对鼻腔反应的了解扩展到两个方面。 共同的环境条件及其相互作用， 导致新的治疗策略。