COCHLEAR MECHANICS

描述：本申请寻求对P.I.的持续支持。的 在基础研究中使用直流敏感激光干涉仪的开创性工作 研究耳蜗隔板的振动。 三个目标是a） 为了更广泛地表征覆膜的振动， P.I.描述了 第一次压缩非线性，B）完成一系列广泛的 基底耳蜗中基底膜振动的研究，以及c）开始 耳蜗中回振动模式的研究。 在心尖 耳蜗，研究将包括广泛的探索范围， 双音失真产品的产生，一个小的，但检查 潜在的显着直流分量，以覆膜振动，和 神经激励的响应相位的分析，依赖于神经和 受体电位记录。 总体目标是一个完整的描述，在 所有的转动，科蒂器官的振动机制。

DESCRIPTION: This application seeks continuing support for the P.I.'s pioneering work in the use of a DC-sensitive laser interferometer in basic studies of the vibration of the cochlea partition. The three goals are a) to perform more extensive characterization of the vibration of the tectorial membrane in the apical cochlea, in which the P.I. has described for the first time a compressive nonlinearity, b) to complete an extensive series of studies of basilar membrane vibration in the basal cochlea, and c) to begin studies of vibration patterns in the cochlea middle turn. In the apical cochlea, studies will include extensive exploration of the ranges of two-tone distortion product generation, an examination of a small but potentially significant dc component to tectorial membrane vibration, and an analysis of the response phase of neural excitation, relying on neural and receptor potential recording. The overall aim is a complete description, in all turns, of the vibratory mechanics of the organ of Corti.