COCHLEAR MECHANICS

人工耳蜗力学

• 批准号: 2393496
• 负责人: William S. Rhode
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2393496
• 关键词: acoustic nerve; auditory nuclei; biomechanics; chinchilla; cochlea; cochlear nerve; interferometry; organ of Corti; sound frequency

DESCRIPTION: This application seeks continuing support for the P.I.'s pioneering work in the use of a DC-sensitive laser interferometer in basic studies of the vibration of the cochlea partition. The three goals are a) to perform more extensive characterization of the vibration of the tectorial membrane in the apical cochlea, in which the P.I. has described for the first time a compressive nonlinearity, b) to complete an extensive series of studies of basilar membrane vibration in the basal cochlea, and c) to begin studies of vibration patterns in the cochlea middle turn. In the apical cochlea, studies will include extensive exploration of the ranges of two-tone distortion product generation, an examination of a small but potentially significant dc component to tectorial membrane vibration, and an analysis of the response phase of neural excitation, relying on neural and receptor potential recording. The overall aim is a complete description, in all turns, of the vibratory mechanics of the organ of Corti.

描述：此应用程序寻求对 P.I. 的持续支持 在基础研究中使用直流敏感激光干涉仪的开创性工作 耳蜗分区振动的研究。 这三个目标是a) 对地盖振动进行更广泛的表征 耳蜗顶端膜，其中 P.I.已描述为 第一次压缩非线性，b）完成一系列广泛的 基底耳蜗基底膜振动的研究，以及 c) 开始 耳蜗中转振动模式的研究。 在心尖部 耳蜗，研究将包括对耳蜗范围的广泛探索 双音失真产物的生成，对一个小但 对盖膜振动潜在重要的直流分量，以及 分析神经兴奋的反应阶段，依靠神经和 受体电位记录。 总体目标是完整的描述， 柯蒂氏器振动力学的所有转变。