ROLE OF SUBCORTICAL AUDITORY NUCLEI IN CONDITIONING

皮层下听觉核团在调节中的作用

• 批准号: 3410720
• 负责人: CHARLES D WOODY
• 金额: $ 16.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3410720
• 关键词: association learning; auditory pathways; auditory stimulus; brain mapping; cats; conditioning; electrophysiology; membrane activity; memory; neurons; neurophysiology; neurotransmitter metabolism; stimulus generalization

Our main research objective is to investigate the cellular basis of associative, discriminative conditioning in a simplified circuit in the mammalian brain in which neural changes can be related to mediation of conditioning. Changes in neural activity and excitability supporting discrimination of a conditioned stimulus from another auditory stimulus will be investigated in neurons of subcortical auditory areas in relation to slowly and rapidly acquired eyeblink conditioning. The short (8-12 ms) latency of the CR is indicative of a reduced throughput circuitry which facilitates the necessary anatomical, electrophysiological and behavioral analyses. Other aims are: 1. To identify the membrane properties of intracellularly studied units that support activity and excitability changes related to conditioning. 2. To distinguish different types of involved cells, their local circuities, and their more distant axonal projections by intracellular injection of marking agents. 3. To study effects of rapidly acting putative neurotransmitters, their blocking agents, and their possible intracellular messengers on subcortical neurons shown to be active in supporting discriminative conditioning. The results should provide significant information about neural mechanisms and pathways in mammals that mediate associative, discriminative conditioning and related aspects of short and long term memory. Further information will be obtained about the role of subcortical neurons in accelerating rates of acquisition of this conditioned response. Present understanding of learning and related phenomena is limited by a lack of specific knowledge. Much of the current medical practice in the areas of 1) rehabilitation of stroke victims, 2) behavioral psychotherapy, and 3) treatment of mental retardation and memory disorders is similarly limited. New knowledge could potentially be applied to these human health care needs.

我们的主要研究目标是研究细胞基础 在一个简单的电路中， 在哺乳动物大脑中，神经变化可能与 条件反射的中介。 神经活动的变化， 支持条件刺激辨别的兴奋性 从另一个听觉刺激将在神经元的研究 皮层下听觉区与慢和快 获得性眨眼条件反射 短（8-12 ms）的潜伏期， CR表示吞吐量降低的电路， 促进必要的解剖学、电生理学和 行为分析 其他目标是： 1. 为了确定细胞内研究的膜特性， 支持活动和兴奋性变化的单位， 条件反射 2. 为了区分不同类型的受累细胞， 回路，以及它们更远的轴突投射， 细胞内注射标记剂。 3. 为了研究快速作用的假定神经递质的作用， 它们的阻断剂和它们可能的细胞内信使 在皮层下神经元上， 辨别性条件反射 这些结果应该提供有关神经系统的重要信息。 在哺乳动物中， 区分性条件反射和短与长的相关方面 术语记忆 将获得有关该角色的进一步信息 皮质下神经元加速这种获取的速度 条件反应 目前对学习的理解和 由于缺乏具体的知识，有关现象的研究受到限制。 多 目前的医疗实践在1）康复领域 中风受害者，2）行为心理治疗，3）治疗 精神发育迟滞和记忆障碍也同样有限。 新的知识可能会应用于这些人类健康 照顾需要。