ENERGY EXPENDITURE AND THE INCIDENCE OF OBESITY

能量消耗和肥胖发生率

• 批准号: 2414915
• 负责人: LINDA G BANDINI
• 金额: $ 27.14万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414915
• 关键词: adolescence (12-20); basal metabolism; bioenergetics; body composition; body physical activity; body water; diet; disease /disorder proneness /risk; female; hormone regulation /control mechanism; human puberty; human subject; longitudinal human study; magnetic resonance imaging; nutrition related tag; obesity; oxygen consumption; parents; prognosis

DESCRIPTION: In the first five years of this project, the principal investigator has completed baseline studies of 197 non-obese, preadolescent girls at high and low risk for the development of obesity as indicated by presence or absence of parental obesity. Data gathered includes the measurement of 24-hour energy expenditure using the doubly labeled water technique, resting metabolic rate, maximal oxygen consumption, body composition (total body water, anthropometry, BIA), as well as physical activity diaries and questionnaires, food diaries and questionnaires, and parental obesity status and activity questionnaires. It is now proposed that this cohort will be followed prospectively to determine whether girls who become obese were those with reduction in one or more components of energy expenditure at baseline. Longitudinal measurements of energy expenditure will be performed in a subcohort, and this information will be used to cross- validate other measures of physical activity. In addition, the investigators propose to measure abdominal fat using magnetic resonance imaging in girls at menarche and four years after menarche. These data will be combined with yearly measurements of plasma hormone concentrations, as well as lifestyle factors, to determine whether these are predictors of visceral fat gain.

描述：在这个项目的头五年里，校长 研究人员已经完成了对197名非肥胖者的基线研究， 青春期前女孩肥胖的高危和低危 如父母肥胖的存在或不存在所示。收集的数据 包括使用DOUBLY 标记水技术，静息代谢率，最大氧气 摄入量、身体成分(全身水分、人体测量、BIA)、AS 以及体育活动日记和调查问卷，食物日记和 问卷调查，以及父母肥胖状况和活动调查问卷。 现在提议，这一队列将前瞻性地跟踪到 确定变得肥胖的女孩是否是那些体重减少的女孩 基准线的能源支出的一个或多个组成部分。纵向 能量消耗的测量将在子队列中进行，以及 这些信息将被用于交叉验证其他措施 体力活动。此外，调查人员建议测量 利用磁共振成像对女性月经初潮和初潮时腹部脂肪的研究 月经初潮后四年。这些数据将与每年 测量血浆激素浓度以及生活方式 以确定这些因素是否是内脏脂肪增加的预测因素。