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ENERGY EXPENDITURE AND THE INCIDENCE OF OBESITY

能量消耗和肥胖发生率

基本信息

批准号：
6381025
负责人：
LINDA G BANDINI
金额：
$ 20.06万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-05-01 至 2003-10-31
项目状态：
已结题

项目摘要

Adolescence in girls is a critical period for the development of obesity. Reduced energy expenditure represents a strong risk factor. We are continuing to follow annually a cohort (originally 197 pre- menarcheal girls) who were enrolled (1990-1993) in a longitudinal study of energy expenditure and its relationship to the development of obesity. One hundred and fifty-nine girls (80.7%) remain active in the study. Of these 159 subjects, 59 have completed the study and the other 100 continue to seen annually. A baseline measures of body composition, resting metabolic rate, total daily energy expenditure, and VO2 max were completed. Measures of diet and activity were obtained from a 7-day food record, a 7-day activity record, and activity questionnaires. Since enrollment, girls are seen annually until 4 years after menarche when they exit the study. At their annual visit, measures of diet, activity, growth and body composition by anthropometric measures are obtained. Blood is drawn for the measurement of sex hormones and insulin. At the end of this proposed grant period, all but five girls will be 4 years post menarcheal and will exit the study. At that time we will have determined whether reductions in energy expenditure at baseline (total daily energy expenditures, resting energy expenditure, percent non- resting energy expenditure or VO2 max) are associated with increases in body fat as girls mature. We will also determine whether differences in ethnicity, or parental obesity contribute to the changes in body fat in a subcohort of girls, visceral fat was previously measured at menarche by MRI. At the time of the MRI, measures of body composition and anthropometry were repeated, blood was drawn for the measurement of sex hormones, and questionnaires were completed rating to diet, activity and behaviors such as smoking and alcohol abuse. We will repeat these measures in these girls at their exit visit. This study will allow us to determine what factors contribute to visceral fat deposition in girls during puberty. These studies will clarify the role of energy expenditure in the development of obesity and identify factors that contribute to the deposition of visceral fat. Identification of factors which contribute to the development of obesity and central fat distribution will aid in the development of programs designed to reduce the incidence and morbidity associated with adolescent obesity.

女孩的青春期是肥胖发展的关键时期。能源支出减少是一个很大的风险因素。我们继续每年跟踪一个队列(最初是197名月经前女孩)，他们参加了一项关于能量消耗及其与肥胖发展关系的纵向研究(1990-1993)。159名女孩(80.7%)仍然活跃在研究中。在这159名受试者中，59名已经完成了研究，其余100名继续每年接受研究。完成了身体成分、静息代谢率、每日总能量消耗和最大摄氧量的基线测量。饮食和活动的测量是从7天的食物记录、7天的活动记录和活动问卷中获得的。自注册以来，女孩每年都会被看到，直到月经初潮后4年退出研究。在他们的年度访问中，通过人体测量测量饮食、活动、生长和身体成分。抽血测定性激素和胰岛素。在这一拟议的资助期结束时，除5名女孩外，所有女孩都将是月经初潮后4年的女孩，并将退出研究。到那时，我们将确定基线能量消耗的减少(每日总能量消耗、静息能量消耗、非静息能量消耗的百分比或最大摄氧量)是否与女孩成熟时身体脂肪的增加有关。我们还将确定种族差异或父母肥胖是否会导致亚队列女孩体内脂肪的变化，内脏脂肪以前是在月经初潮时通过核磁共振测量的。在核磁共振检查时，重复测量身体成分和人体测量，抽血测量性激素，并完成问卷调查，对饮食、活动和吸烟、酗酒等行为进行评级。我们将在这些女孩的出境探视中重复这些措施。这项研究将使我们能够确定哪些因素对青春期女孩的内脏脂肪沉积起作用。这些研究将阐明能量消耗在肥胖发展中的作用，并确定有助于内脏脂肪沉积的因素。确定导致肥胖和中心脂肪分布的因素将有助于制定旨在减少与青少年肥胖相关的发病率和发病率的方案。