ULTRAVIOLET RADIATION INDUCED SKIN CANCER

紫外光照射抑制迟发性肺炎的诱导和激发 部分患者有超敏反应(DTH)，但不是全部。我们有 开发了一种使用激光多普勒血流成像的定量方法 UV-AB诱导抑制迟发型超敏反应的分析 以前的结核菌素-PPD致敏个体的反应 紫外线剂量与诱导剂量效关系研究 指对紫外线诱导的抑制的抑制或抵抗。十九个健康的 志愿者们被连续四天每天照射在 上背部有UV-AB辐射。UV-AB剂量水平调整为 发射60或120 mJ/cm2的UV-B辐射。在第四天，一 为每个紫外线剂量选择一个照射的和一个未照射的测试点 随机对每个人进行注射，皮内注射结核菌素。 临床试验反应在j96h进行分析和量化。 激光多普勒血流成像。结果表明，UV-AB 放射治疗对迟发型结核菌素诱导期的抑制作用 超敏免疫反应和剂量依赖和 紫外线免疫抑制作用的个体差异 辐射。在低剂量(UV-B)下，敏感和耐药 观察到的表型比例约为1：1。 将UV-B的剂量加倍，会增加一些个体的抑制作用， 在其他抗性个体中诱导抑制，或诱导 其他对较低剂量敏感的抗药性或耐受性 紫外光。我们假设紫外线诱导的抑制的阈值 迟发型超敏反应与T抑制细胞的诱导 差异很大。因此，对UVR和UVR的描述 诱导敏感性或耐药性的剂量-反应关系 必须确定，以便充分表现这些性状。 人类群体中的这些表型差异可能被用来 确定皮肤癌风险增加是否发生在符合以下条件的人中 被压制了。

UV radiation suppresses the induction and elicitation of delayed-type hypersensitivity (DTH) in some individuals, but not all. We have developed a quantitative method using laser Doppler perfusion imaging analysis of UV-AB induced suppression of DTH using the elicitation response in previously tuberculin-PPD sensitized individuals in order to investigate the dose response relationship between UV dose and induction of suppression or resistance to UV induced suppression. Nineteen healthy volunteers were irradiated daily for four days on delineated areas on the upper back with UV-AB radiation. UV-AB dose levels were adjusted to deliver 60 or 120 mJ/ cm2 UV-B radiation. On the fourth day, one irradiated and one unirradiated test site for each UV-dose were chosen at random on each individual and injected intradermally with tuberculin. Test reactions were analyzed and quantified at j96 h clinically and with laser Doppler perfusion imaging. The results indicate that UV-AB radiation can suppress the elicitation phase of tuberculin delayed type hypersensitivity immune reaction and that there are dose dependent and individual differences in the immune suppressive effect of the UV- radiation. at low dose (UV-B), both the susceptible and resistant phenotypes were observed at an approximate ratio of 1:1. However, doubling the dose of UV-B increased the suppression in some individuals, induced suppression in others that were resistant, or induced a resistance or tolerance in others that were susceptible at the lower dose of UV. We hypothesize that the thresholds for UV induced suppression of DTH and the induction of T suppressor cells that may block elicitation vary considerably. Thus, characterization of both the UVR and the UVR dose response relationship for induction of susceptibility or resistance must be determined in order to adequately phenotype for these traits. These phenotypic differences in the human population may be used to determine if increased risks to skin cancer occurs in individuals who are suppressed.