HIV IN INJECTION DRUG USERS

注射吸毒是艾滋病毒日益流行的辅助因素 在美国的传播，导致增加的比率 传播到异性伴侣中并显著增加 母婴传播。在本财年，模型系统的研究 完成了对注射器的消毒，显示出艾滋病毒的持久性 由有经验的人使用的注射器清洗程序后的遗传物质 吸毒研究志愿者注射吸毒者(IDU志愿者)。 在分析来自活跃人群的病毒载量研究的数据时- 自我注射的注射吸毒者，高水平的HIV-1循环是 在外周白血球和血浆中检测到。比较 检测技术显示，艾滋病毒捕获/聚合酶链式反应显示最大 静脉吸毒人群中HIV-1检测的敏感性。这些研究正在进行 辅以艾滋病毒携带者的药物奖励研究 痴呆症/脑病目前处于规划阶段。

Injection drug use is an increasingly-prevalent cofactor for HIV transmission in the United States, leading to increased rates of transmission into the heterosexual partners and marked increases in maternal-fetal transmission. During this FY, studies of model systems for syringe disinfection were completed that reveal persistance of HIV genetic material after syringe-washing procedures employed by experienced drug abusing research volunteer injection drug users (IDU volunteers). In analyzing data from viral load studies from a population of actively- self-administering IDU volunteers, high levels of circulating HIV-1 were detected in peripheral white blood cells and in plasma. Comparisons of detection techniques revealed that HIV capture/PCR displayed maximal sensitivity for detecting HIV-1 in the IDUs. These studies are being supplemented by studies of drug reward in individuals with HIV dementia/encephalopathy currently in planning stages.