IN VIVO ASSESSMENTS IN DRUG USERS

药物使用会对组织产生影响，并可能由特定的 使用成像方法在体内检测变化可能是最好的 寻求与毒品有关或由毒品引起的个体差异 虐待。在本财年，我们将先进的统计分析应用于 心肌SPECT血流灌注数据显示斑片状微血管 有心肌梗塞病史的研究志愿者的心肌灌注缺陷 慢性可卡因自我给药与年龄数据的比较 将没有药物滥用史的志愿者配对。我们是 完成18F-脱氧葡萄糖代谢脑的合作研究 与可卡因渴求程度相关的变化 与慢性可卡因使用者和对照组接触可卡因- 相关的刺激。我们正在开始研究寻找两者之间的关联 不同神经递质受体的多态基因标记 用单光子和正电子在体内测量受体密度-- 成像技术。

Drug use exerts tissue consequences and may be predisposed by specific alterations likely to be best detected in vivo using imaging approaches that seek individual differences predisposing to or consequent of drug abuse. In this FY, we have applied advanced statistical analyses to myocardial SPECT perfusion data to document patchy microvascular myocardial perfusion defects in research volunteers with histories of chronic cocaine self-administration, in comparison to data from age matchedvolunteers without histories of substance abuse. We are completing collaborative studies of 18F-deoxyglocose metabolic brain changes that correlate with the extent of cocaine craving experienced with chrronic cocaine users and controls are exposed to cocaine- associated stimuli. We are beginning studies that seek correlates between polymorphic gene markers at different neurtransmitter receptors and receptor densities measured in vivo using single-photon and positron- imaging techniques.