MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS

白细胞激活和趋化机制

基本信息

  • 批准号:
    2722957
  • 负责人:
  • 金额:
    $ 23.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-02-01 至 2003-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Adapted from applicant's abstract): Leukocytes play an important role in host defense against invading microorganisms. Their ability to generate superoxide radicals and release degradative enzymes following migration to sites of inflammation is essential for this function. However, these same responses can also participate in the formation of numerous pathological conditions. The re-introduction of blood flow to ischaemic tissues following myocardial thrombosis, stroke or frostbite is responsible for the observed tissue damage, which can be alleviated by the depletion of neutrophils. Chemoattractants elicit their effects on neutrophils by binding to cell surface receptors coupled to guanine nucleotide-binding regulatory proteins (G proteins). The goal of this work is to understand the molecular mechanisms involved in the activation of leukocyte G protein-coupled chemoattractant receptors as they pertain to receptor signaling and processing, receptor interactions with the cytoskeleton and chemotaxis. The specific aims of this proposal include the determination of the role of the N-formyl peptide receptor (FPR) activation I the physical binding of the receptor to G protein. The proposed experiments will also determine residues responsible for the interaction of the receptor with the cytoskeleton and one of its major components, actin. We will generate mutations in the intracellular domains of the recombinant FPR and express these in tissue culture cell lines for functional analysis. The roles of specific residues, including potentially phosphorylated residues, will be determined with respect to receptor processing and chemotaxis utilizing a novel system we have recently developed. These complex activities likely require interactions following receptor phosphorylation. Utilizing this system, we will also examine the role(s) of the low MW G proteins rho, rac and cdc42 in leukocyte chemotaxis. Information obtained from the proposed studies is expected to extend our knowledge of the activation of signal transduction pathways by chemoattractant receptors with the long term goal that such knowledge will lead to the development of therapeutic means to control neutrophil activation and prevent the tissue damage resulting from the excessive activation of neutrophils following reperfusion.
描述(改编自申请人摘要):白细胞起作用

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Eric R Prossnitz其他文献

Eric R Prossnitz的其他文献

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{{ truncateString('Eric R Prossnitz', 18)}}的其他基金

G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    8517052
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    8677811
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    10472699
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
Assay Implementation
检测实施
  • 批准号:
    8443194
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    10251268
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    8849761
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    10689300
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
G protein-coupled estrogen receptor GPER and breast carcinogenesis
G蛋白偶联雌激素受体GPER与乳腺癌发生
  • 批准号:
    9079447
  • 财政年份:
    2012
  • 资助金额:
    $ 23.88万
  • 项目类别:
MLP Assay for Arrestin-AP2 Inhibitors
Arrestin-AP2 抑制剂的 MLP 测定
  • 批准号:
    8208096
  • 财政年份:
    2011
  • 资助金额:
    $ 23.88万
  • 项目类别:
MLP Assay for Arrestin-AP2 Inhibitors
Arrestin-AP2 抑制剂的 MLP 测定
  • 批准号:
    8069438
  • 财政年份:
    2011
  • 资助金额:
    $ 23.88万
  • 项目类别:

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由两类细菌肌动蛋白 MreB 驱动的新型运动系统
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多种植物肌动蛋白的差异表达
  • 批准号:
    7931495
  • 财政年份:
    2009
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Studies on how actins and microtubules are coordinated and its relevancy.
研究肌动蛋白和微管如何协调及其相关性。
  • 批准号:
    19390048
  • 财政年份:
    2007
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    Grant-in-Aid for Scientific Research (B)
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拟南芥生殖肌动蛋白的抑制
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    6655612
  • 财政年份:
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Suppression of Arabidopsis Reproductive Actins
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肌球蛋白与单体肌动蛋白的相互作用
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  • 财政年份:
    2001
  • 资助金额:
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STRUCTURE/INTERACTIONS OF ACTINS AND ACTIN-BINDING PROTEIN
肌动蛋白和肌动蛋白结合蛋白的结构/相互作用
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    6316669
  • 财政年份:
    2000
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