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ECOG C9344 DOXORUBICIN DOSE ESCALATION +/- TAXOL FOR NODE POSITIVE BREAST CANCER

ECOG C9344 DOXORUBICIN DOSE ESCALATION +/- TAXOL FOR NODE POSITIVE BREAST CANCER
ECOG C9344 阿霉素剂量递增/- 紫杉醇治疗淋巴结阳性乳腺癌
批准号：
6246887
负责人：
RONALD BLUM
金额：
$2.39万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-12 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246887
关键词：
breast neoplasms clinical research combination chemotherapy cyclophosphamide dosage doxorubicin drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy paclitaxel

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英文摘要
This randomized Phase III study compares a standard dose of cyclophosphamide and 3 different doses of doxorubicin with and without Taxol in patients with lymph node positive-breast cancer. The primary objectives of this study are to determine whether higher doses of doxorubicin with cyclophosphamide in patients with early breast cancer will increase disease-free and overall survival; to determine whether use of single-agent Taxol after the above therapy will improve survival; to compare efficacy of Taxol in combination with high dose vs. standard dose cyclophosphamide and doxorubicin; and to assess the toxicities of the various regimens.
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