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SWOG 94-20 CORRELATION OF THYMIDYLATE SYNTHASE IN 5 FU TREATED COLORECTAL CANCER

SWOG 94-20 CORRELATION OF THYMIDYLATE SYNTHASE IN 5 FU TREATED COLORECTAL CANCER
SWOG 94-20 胸苷酸合酶在 5 FU 治疗的结直肠癌中的相关性
批准号：
6246884
负责人：
RONALD BLUM
金额：
$2.39万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-12 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246884
关键词：
5 fluorouridine antineoplastics clinical research clinical trials colorectal neoplasms combination chemotherapy human subject neoplasm /cancer chemotherapy neoplasm /cancer pharmacology polymerase chain reaction thymidylate synthase

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中文摘要
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英文摘要
This is a randomized trial of two different methods of administering 5-FU plus leukovorin in the treatment of colon cancer. Samples of the tumor will be assayed for thymidylate synthase (TS) message by RT-PCR, following which the patients will be randomized to receive intermittent high dose 5- FU infusion or continuous low dose infusion. Patients will continue to receive the same therapy until either toxicity or poor response occurs. Response will be correlated with apparent TS levels.
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