SWOG 94-20 CORRELATION OF THYMIDYLATE SYNTHASE IN 5 FU TREATED COLORECTAL CANCER

SWOG 94-20 胸苷酸合酶在 5 FU 治疗的结直肠癌中的相关性

• 批准号: 6246884
• 负责人: RONALD BLUM
• 金额: $ 2.39万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-12 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246884
• 关键词: 5 fluorouridine; antineoplastics; clinical research; clinical trials; colorectal neoplasms; combination chemotherapy; human subject; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; polymerase chain reaction; thymidylate synthase

This is a randomized trial of two different methods of administering 5-FU plus leukovorin in the treatment of colon cancer. Samples of the tumor will be assayed for thymidylate synthase (TS) message by RT-PCR, following which the patients will be randomized to receive intermittent high dose 5- FU infusion or continuous low dose infusion. Patients will continue to receive the same therapy until either toxicity or poor response occurs. Response will be correlated with apparent TS levels.

这是一项关于两种不同的5-FU给药方法的随机试验 再加上leukovorin治疗结肠癌。肿瘤样本 将通过RT-PCR测定胸苷酸合酶（TS）信息， 患者将随机接受间歇性高剂量5- FU输注或持续低剂量输注。患者将继续 接受相同的治疗，直到出现毒性或不良反应。 反应将与表观TS水平相关。