GASTROINTESTINAL LYMPHATIC TISSUE SAMPLING TO DETERMINE ACTIVE HIV1 REPLICATE

胃肠道被认为是人类最大的淋巴器官。 基于物理尺寸的身体。之前的调查人员已经 证明HIV-1感染细胞在淋巴中数量更多 组织比外周血中的含量要高。我们假设内脏与 淋巴组织(GALT)可作为HIV-1感染和 可以提供一种跟踪治疗反应的灵敏方法 到HIV-1感染患者的抗逆转录病毒药物治疗。本研究 将提供淋巴组织用于HIV-1定量和许可评估 淋巴组织对治疗的反应中的细胞变化 用抗逆转录病毒药物治疗。

The gastrointestinal tract is considered the largest lymphoid organ in the body based on physical dimensions. Previous investigators have demonstrated that HIV-1 infected cells are more numerous in the lymphoid tissue than in peripheral blood. We hypothesize that the Gut Associated Lymphoid Tissue (GALT) may serve as a resevoir for HIV-1 infection and may provide a sensitive method by which to follow the therapeutic response to antiretroviral medication in patients with HIV-1 infection. This study will provide lymphatic tissue for HIV-1 quantitation and permit evaluation of the cellular changes in the lymphatic tissue in response to treatment with antiretroviral medication.