GASTROINTESTINAL LYMPHATIC TISSUE SAMPLING TO DETERMINE ACTIVE HIV1 REPLICATE

有令人信服的理论理由来研究接受抗逆转录病毒药物治疗的hiv感染者肠道相关淋巴组织（GALT）中的病毒和免疫反应。GALT约占机体淋巴组织的50%，在许多患者中，GALT是HIV的初始接种部位，GALT中的绝大多数淋巴细胞表达记忆表型标记（如CD45RO），并被慢性激活，从而增强了这些细胞的HIV感染。面对强效抗逆转录病毒联合药物，我们将评估感染艾滋病毒的衰变细胞以及被困在该体室的fdc网络中的艾滋病毒。我们还将评估CD4+淋巴细胞在外周血中再生之前可能发生的GALT中的再生率。

There are compelling theoretical reasons to study the viral and immune response in the gut-associated lymphoid tissue (GALT) in HIV-infected individuals who have been treated with antiretroviral medication. The GALT contains approximately 50% of the lymphoid mass in the body, it serves as the site of initial HIV inoculation in many patients, and the vast majority of the lymphocytes in the GALT express memory phenotypic markers (e.g., CD45RO) and are chronically activated, which enhances HIV infection of these cells. We will evaluate the decay cells infected with HIV as well as trapped HIV in the FDC-network in this body compartment in the face of potent combination antiretroviral medication. We will also evaluate the repopulation rate of CD4+ lymphocytes in the GALT that may occur prior to their repopulation in the peripheral blood.